摘要
恶性肿瘤已成为影响人类健康的主要原因,绝大多数尚缺乏高敏感度和特异度的诊断指标和治疗靶点.RNA甲基化修饰是近年来前沿研究热点,肿瘤组织、细胞和患者外周血中RNA甲基化修饰谱和修饰水平变化与肿瘤发生、发展、预后密切相关,具备作为肿瘤精准诊断和治疗的靶标潜能.尽管目前RNA甲基化修饰检测方法学、作用机制研究和基于RNA甲基化修饰治疗药物的研发仍面临诸多挑战,但其作为肿瘤液体活检指标研究的新方向,展现出良好的临床价值和转化潜能,可为肿瘤的精准诊断、治疗靶标和药物研发提供新的策略和方向.
Abstract
Malignant tumors have become the main threaten of human health,however,highly sensitive and specific diagnostic biomarkers and effective therapeutic targets are still lacking for most cancers currently.RNA methylation modification has been a cutting-edge hotspot in RNA research area in recent years.The dynamic changes of RNA methylation patterns and levels in tumor tissues,cells as well as patients'peripheral blood are closely associated with tumor occurrence,development,and prognosis,and have the potential to serve as precise diagnostic markers and effective therapeutic targets for tumors.Even though several challenges such as RNA methylation detection methods,functional mechanism,and the development of therapeutic drugs based on RNA methylation modification are needed to solve,from lab to clinical practice,RNA methylation still display excellent diagnostic and prognosis performance,which can provide new strategies and evidence for precise diagnosis,treatment targets,and drug development of tumors.
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