Non-invasive prenatal testing(NIPT)is a prenatal screening method that uses high-throughput gene sequencing technology to detect fetal free DNA fragments in maternal peripheral blood,in order to evaluate the risk of common chromosomal aneuploidy(T21,T18,T13)in fetuses.It has made great contributions to the prevention and treatment of birth defects.To ensure the accuracy and reliability of the testing results,it is necessary to add quality control materials for strict quality control throughout the entire testing process.However,most testing platforms lack plasma quality control materials during plasma extraction.Universal plasma quality control materials are also needed in the external quality assessment on different platforms.To solve this quality control problem,six strategies for the preparation of NIPT plasma control materials have emerged in recent years,with different application ranges,advantages and disadvantages based on their different sources of matrix and positive DNA.
关键词
产前诊断/无创产前基因检测/质控物/自制/质量控制
Key words
Prenatal diagnosis/Non-invasive prenatal testing/Quality control materials/Self-control/Quality control
维普
万方数据