Clinical evaluation of 2021 CKD-EPI equation and EKFC equation for estimated glomerular filtration rate
Objective To retrospectively compare the clinical effects of the 2021 Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI)equation and the European Kidney Function Consortium(EKFC)equation based on creatinine to estimate glomerular filtration rate(eGFRcr)in a Chinese population.Methods Patients and healthy individuals who visited the Zhongshan Hospital,Fudan University,between January 1,2023,and December 31,2023,were enrolled.The exclusion criteria were age＜18 years,amputees,pregnant women,patients with muscle-related diseases,and patients who had undergone ultrafiltration or dialysis.The final study population included 660 078 individuals with a median age of 58 years(44,68),56.51％(372 987/660 078)of them were men.eGFRcr was calculated using the 2021 CKD-EPI,EKFC equations and initial 2009 CKD-EPI equation.Results were compared by differences(P10),charges in population distribution and impact on staging of chronic kidney disease(CKD)by gender,age and creatinine results.Results Compared with the results of 2009 and 2021 CKD-EPI eGFRcr,the P1owas 99.99％(R2=0.997).When applying the 2021 CKD-EPI eGFRcr equation,there was a slight overestimation of 3.77(2.92,4.47)ml/(min×1.73 m2).86.42％(570 455/660 078)participants had higher eGFRcr owing to the utilization of the 2021 CKD-EPI equation,which did not cause CKD stage change.A total of 12.35％(81 514/660 078)of subjects had different CKD stage with the higher 2021 CKD-EPI eGFRcr.1.23％(8 109/660 078)had lower eGFRcr but no change in the CKD stage with the 2021 equation.Compared to the 2009 CKD-EPI eGFRcr results,the EKFC eGFRcr demonstrates P10 values of 89.79％,with a correlation coefficient of R2=0.976.The overall eGFRcr values using the EKFC equation were decreased by 4.63(-2.22,-7.04)ml/(min×1.73 m2).There were 75.14％(495 992/660 078)individuals whose eGFRcr results were lower in EKFC equation,which did not cause CKD stage change.There were 15.63％(103 161/660 078)leading to a different CKD stage.Additionally,8.80％(58 077/660 078)individuals with a higer eGFRcr result did not change CKD stage,while 0.43％(2 848/660 078)experienced a change in CKD staging due to the overestimation.Conclusions Compared with the 2009 CKD-EPI eGFRcr results,the 2021 CKD-EPI eGFRcr results were slightly higher and had good consistency in different genders and ages.However,the EKFC eGFRcr was generally lower than 2009 CKD-EPI eGFRcr,showing poor consistency.The differences between eGFR equations should be considered when judging the CKD stage of patients.
万方数据
维普
