To explore the controversies and considerations at the strategic level triggered by the popularization of cancer susceptibility gene testing,this article focuses on the testing population,gene panel,and testing methods.By integrating the latest research advances,clinical practice experiences,and expert opinions,it describes the factors to consider when selecting different strategies.Concurrently,the article discusses the current challenges in cancer susceptibility gene testing.While cancer susceptibility gene testing holds significant importance in cancer prevention and individualized treatment,comprehensive consideration of various factors in clinical practice is essential for promoting its beneficial development and broader application.