首页|肿瘤基因测序技术在非小细胞肺癌临床分子诊断中的应用

肿瘤基因测序技术在非小细胞肺癌临床分子诊断中的应用

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非小细胞肺癌(NSCLC)居我国乃至全球恶性肿瘤首位,近年来基因检测技术,尤其是肿瘤基因测序技术的发展,为NSCLC的临床分子诊断提供了坚实的依据,极大地提高了患者从靶向治疗或免疫治疗中获益的可能性,显著延长了患者的生存期.如何规范化利用肿瘤基因测序技术为NSCLC精准医疗提供依据尤为重要.本文就肿瘤基因测序技术在NSCLC临床分子诊断路径中应用的规范化进行了探讨,有利于推动肿瘤基因测序技术在NSCLC患者靶向治疗或免疫治疗药物的选择、毒副作用预测、疗效监测、复发及预后评价等中的规范化应用,也为肿瘤基因测序技术在其他实体瘤中的规范化应用提供了依据.
Application of tumor gene sequencing technology for clinical molecular diagnosis of non-small cell lung cancer
Non-small cell lung cancer(NSCLC)ranks the first among malignant tumors in China and even in the whole world.In recent years,the developement of genetic testing technology,particularly tumor gene sequencing,has provided a solid basis for the clinical molecular diagnosis of NSCLC,which has greatly increased the chances of patients benefiting from targeted therapy or immunotherapy,and ultimately extending their survival.Standardizing the use of tumor gene sequencing is crucial for the precision medicine in NSCLC.This paper discusses the normalization of tumor gene sequencing technology in the clinical molecular diagnostic pathway of NSCLC,which may promote the standardized use of tumor gene sequencing technology in targeted therapy or immunotherapy drug selection,toxicity and side effect prediction,efficacy monitoring,recurrence and prognosis evaluation of NSCLC patients.This article discusses the standardization of the application of tumor gene sequencing technology in the clinical molecular diagnosis pathway of NSCLC.Additionally,it offers a foundation for the uniform use of tumor gene sequencing technology in other solid tumors.

NeoplasmsSequenceCarcinoma,non-small-cell lungMolecular targeted therapy

朱鲲博、袁梦馨、王京伟、顾剑、吴茜、徐万洲、童永清

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武汉大学人民医院检验医学中心,武汉 430060

武汉大学临床分子诊断研究所,武汉 430060

肿瘤 测序 癌,非小细胞肺 分子靶向治疗

2024

中华检验医学杂志
中华医学会

中华检验医学杂志

CSTPCD北大核心
影响因子:1.402
ISSN:1009-9158
年,卷(期):2024.47(11)