Tumors pose a serious challenge to global public health.The sensitive and precise detection of tumor biomarkers is very important for early screening and diagnosis of cancers.DNAzymes with outstanding physical,chemical,and biological properties are widely applied in the design of biosensing strategies.By the use of sensing platforms such as fluorescence,electrochemistry,and surface-enhanced Raman scattering,DNAzymes facilitate the early screening and detection of tumors.This article summarizes the functional mechanism and common classifications of DNAzymes,and the updates of DNAzymes-based novel biosensing technologies within the field of liquid biopsy,expecting the technical challenges yet to be surmounted and future developmental directions.
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