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嘉兴地区近平滑假丝酵母菌感染回顾性研究

Retrospective analysis of Candida parapsilosis infections in Jiaxing area

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目的 对嘉兴地区近平滑假丝酵母菌感染情况进行研究,以指导临床经验性用药和控制医院感染.方法 回顾性总结近6年来医院近平滑假丝酵母菌感染率及药敏率,药敏试验用法国生物梅里埃公司ATB FUNGUS3真菌药敏试剂条.结果 近平滑假丝酵母菌感染从无到有,6年共分离出近平滑假丝酵母菌214例,自2006年起开始分离到,2007年以后呈逐年增加趋势,2010年占总分离率的0.60%;感染者年龄1月龄~89岁,男性多于女性;病区分布以ICU为主,占32.07%,其次为手足外科占16.30%、儿科占9.78%、脑外科占8.70%、烧伤科占8.15%等;标本分布中以尿液、分泌物、导管、血液居多;药敏试验共82例,对5种常见抗真菌药物:5-氟胞嘧啶、两性霉素B、氟康唑、伊曲康唑、伏立康唑的药敏结果显示,除1株对伏立康唑耐药外,其余均敏感.结论 及时监测医院中病原菌,对指导临床经验性用药和控制医院感染有重要意义.
OBJECTIVE To study Candida parapsilosis infection condition in Jiaxing area, so as to guide the empirical use of antibiotics and the control of nosocomial infections. METHODS The rate of C. parapsilosis infection and the drug susceptibility during the past 6 years were retrospectively summarized) the drug susceptibility testing was performed by using ATB FUNGUS 3 reagent. RESULTS A total of 214 strains of C. parapsilosis were isolated during recent 6 years, from the start of the isolation , it kept an increasing tendency ever since 2007 , the isolation rate in 2010 was 0. 60% ; the age of the patients with infections varied from 51 days to 89 years old, and the male exceeded the females the infections primarily occurred in ICU (32. 07%), followed by hand and foot surgery department (16. 30%), department of pediatrics (9. 78%), department of cerebral surgery (8.70%), and burn departmenl (8. 15%); ihese isolates were mainly isolated from urine, secretion, catheter , and blood; totally 82 strains were available for antifungal susceptibility testing which indicated that all strains were susceptible to flucytosine, amphotericin B, fluconazole, and itraconazole except that one strain was resistant to voricanozole. CONCLUSION To monitor the pathogens in hospital in a time manner is very important [or the empirical medication and the control of nosocamial infections.

Candida parapsilosisInfectionDrug sensitivity testResearch

宋国蓉、吴晓燕、倪侃翔、陈松劲

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嘉兴市第二医院检验科,浙江嘉兴314000

近平滑假丝酵母菌 感染 药敏试验 研究

2012

中华医院感染学杂志
中华预防医学会 中国人民解放军总医院

中华医院感染学杂志

CSTPCDCSCD北大核心
影响因子:1.885
ISSN:1005-4529
年,卷(期):2012.22(9)
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