神经外科病房铜绿假单胞菌的暴发流行调查
Prevalence of Pseudomonas aeruginosa infections in department of neurosurgery
王娟 1兰海丽 1张秀明 1吴秀娟 1慕月晶 1严海忠 1苏丹婷1
作者信息
- 1. 中山大学附属中山市人民医院检验医学中心,广东中山528403
- 折叠
摘要
目的 调查分析神经外科病房医院感染的情况,对神经外科铜绿假单胞菌暴发感染进行流行病学调查分析,为预防和控制医院感染提供参考资料.方法 对2012年1月30日-2月3日分离于神经外科的4例医院感染铜绿假单胞菌进行流行病学调查,分析其耐药表型,并用多位点串联重复序列基因(MLVA)分型进行分析.结果 4例铜绿假单胞菌株均有相同耐药菌谱,除对哌拉西林/他唑巴坦敏感外,对其余药物均耐药,包括三代头孢菌素、碳青霉烯类药物；ML VA基因分型中,4株细菌具有相同的基因图谱,说明4株菌株为同一流行株；4例患者的流行病学调查显示,均属于同一医师治疗组,且均有脑部手术史,住院时间＞8个月.结论 此次分离于神经外科的铜绿假单胞菌感染为局部暴发流行,应根据药敏试验结果选用抗菌药物,医师与护士应严格执行无菌技术操作,加强基础护理和病房环境管理,重视医务人员的交叉感染.
Abstract
OBJECTIVE To explore the epidemiological features of Pseudomonas aeruginosa infections in department of neurosurgery so as to provide reference for the prevention of nosocomial infections.METHODS The epidemiological survey was conducted for the 4 strains of P.aeruginosa isolated from the neurosurgery department from Jan 30 to Feb 3,2012,the drug resistance phenotype was analyzed,and the multiple-locus variable-number tandem repeat analysis (MLVA) was employed to analyze the genotyping.RESULTS All of the four strains of P.aeruginosa had the same drug resistance spectrum and were sensitive to all the antibiotics except piperacillin/tazobactam,including the third generation cephalosporins and carbapenems.The MLVA genotyping results showed the four strains had the same gene mapping,indicating that the four strains were the same prevalent strain; the epidemiology survey of the 4 patients revealed that the patients were treated by the same group of clinicians and all underwent the cerebral surgery,with the hospitalization duration more than 8 months.CONCLUSION The P.aeruginosa infection is only p revalent in the neurosurgery department.It is necessary to use antibiotics based on the result of drug susceptibility testing,implement the aseptic operation rigidly,strengthen the basic nursing and ward environment management,and focus on the prevention of the cross-infections.
关键词
铜铝假单胞菌/医院感染/MLVA基因分型/暴发流行Key words
Pseudomonas aeruginosa/Nosocomial infection/MLVA genotype/Outbreak and prevalence引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据