Research progress on polymyxin resistance gene mcr-1
Polymyxin is the final choice for the treatment of gram-negative bacteria such as Acinetobacter bauman-nii ,Pseudomonas aeruginosa and Klebsiella pneumoniae .In 2015,Chinese scientists reported the plasmid-media-ted polymyxin resistance gene mcr-1 for the first time.Different from the polymyxin resistance mechanism that has been found,the mcr-1 gene is integrated into the plasmid rather than the chromosome and can be transmitted horizontally in different bacteria with the conjugation of the plasmid.A variety of bacterial and animal hosts can carry the mcr-1 gene.Mcr-1 gene can co-exist with other drug resistance genes in the plasmid,which will result in multidrug resistance and cause serious infection in clinical patients.At present,more than 30 countries on five con-tinents have reported mcr-1 gene,which is a great challenge to global antibiotic resistance.We reviewed the epide-miological patterns of food chain transmission,the prevalence of environment and population,and the outbreak of infection of Klebsiella pneumoniae carrying mcr-1 gene.We hope this review could provide references for antimi-crobial drug resistance.
NETL
NSTL
万方数据
维普
