细菌性肺炎患者CD40L、CD64、sTREM-1水平及其预后价值
CD40L,CD64 and sTREM-1 levels of patients with bacterial pneumonia and their values in prediction of prognosis
冯贺强 1吴鸿滨 1张彩红 1何丽杰 1李玉芬 1肖晓琳2
作者信息
- 1. 天津市第五中心医院检验科,天津 300450
- 2. 天津市第五中心医院中心实验室,天津 300450
- 折叠
摘要
目的 探讨外周血CD40配体(CD40L)、簇分化抗原64(CD64)、可溶性髓系细胞触发受体-1(sTREM-1)水平对细菌性肺炎患者预后价值.方法 选取2021年12月-2023年1月天津第五中心医院收治的198例细菌性肺炎患者为研究对象,根据所选患者的预后情况将其分为预后良好组142例和预后不良组56例,多因素Logistic回归分析细菌性肺炎患者预后不良的危险因素,受试者工作特征(ROC)曲线分析CD40L、CD64、sTREM-1水平对细菌性肺炎预后的预测价值.结果 两组临床肺部感染评分(CPIS)、急性生理学与慢性健康状况评分Ⅱ(APACHE Ⅱ)评分及外周血CD40L、CD64、sTREM-1水平比较,差异有统计学意义(P＜0.05);多因素Logistic回归分析结果显示,CPIS、APACHE Ⅱ评分及高水平CD40L、CD64、sTREM-1是细菌性肺炎患者预后不良的独立危险因素(P＜0.05);外周血CD40L、CD64、sTREM-1水平联合预测细菌性肺炎患者预后的曲线下面积(AUC)值为0.944.结论 细菌性肺炎患者预后的危险因素与CPIS、APACHE Ⅱ评分及外周血CD40L、CD64、sTREM-1水平偏高有关,且外周血CD40L、CD64、sTREM-1水平联合检测对细菌性肺炎患者预后的预测价值更高.
Abstract
OBJECTIVE To explore the values of peripheral blood CD40 ligand(CD40L),cluster differentiation an-tigen 64(CD64)and soluble triggering receptor expressed on myeloid cells-1(sTREM-1)in prediction of progno-sis of the patients with bacterial pneumonia.METHODS A total of 198 patients with bacterial pneumonia who were treated in Tianjin Fifth Hospital from Dec 2021 to Jan 2023 were recruited as the research subjects and were divided into the favorable prognosis group with 142 cases and the poor prognosis group with 56 cases according to the prognosis of the enrolled patients.Multivariate logistic regression analysis was performed for the risk factors for the poor prognosis of the bacterial pneumonia patients.The values of CD40L,CD64 and sTREM-1 in predic-tion of the prognosis were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS There were significant differences in clinical pulmonary infection score(CPIS),acute physiology and chronic health eval-uation(APACHE Ⅱ)score,peripheral blood CD40L,CD64 and sTREM-1 levels between the two groups(P＜0.05).Multivariate logistic regression analysis showed that CPIS,APACHE 11 score and high levels of CD40L,CD64 and sTREM-1 were the independent risk factors for the poor prognosis of the patients with bacterial pneu-monia(P＜0.05).The area under curve(AUC)of the joint detection of peripheral blood CD40L,CD64 and sTREM-1 was 0.944 in prediction of prognosis of the patients with bacterial pneumonia.CONCLUSION The risk factors for the prognosis of the patients with bacterial pneumonia are associated with CPIS,APACHE Ⅱ score and high levels of peripheral blood CD40L,CD64 and sTREM-1.The value of the joint detection of peripheral blood CD40L,CD64 and sTREM-1 is higher in prediction of the prognosis of the patients with bacterial pneumonia.
关键词
细菌性肺炎/CD40配体/簇分化抗原64/可溶性髓系细胞触发受体-1/危险因素/预测价值Key words
Bacterial pneumonia/CD40 ligand/Cluster differentiation antigen 64/Soluble triggering receptor ex-pressed on myeloid cells-1/Risk factor/Predictive value引用本文复制引用
基金项目
国家自然科学基金资助项目(81900407)
出版年
2024
NETL
NSTL
维普
万方数据