Clinical characteristics of patients with non-tuberculous mycobacteriosis,distribution and drug resistance of clinical isolates
OBJECTIVE To explore the clinical characteristics of the patients with non-tuberculous mycobacteriosis and observe the distribution and drug resistance of clinical isolates.METHODS A total of 104 patients with non-tu-berculous mycobacteriosis who were treated in Wuxi Fifth People's Hospital from May 2020 to Feb 2023 were re-cruited as the research subjects.The baseline data of the patients,clinical characteristics,distribution and drug resistance of the clinical isolates were observed.RESULTS Among the patients with non-tuberculous mycobacteri-osis,77.88％had cough and expectoration,and 27.88％had fever.31.73％were complicated with pulmonary emphysema,and 23.08％were complicated with bronchiectasis.100.00％had patches and nodules,81.73％had changes in bronchiectasia,and 51.92％had cavities.Totally 104 strains of non-tuberculous Mycobacteria were i-solated,44.23％of which were Mycobacterium intracellulare,25.00％were Mycobacteria chelonae subsp.ab-scessus,12.50％were Mycobacterium avium,and 10.58％were Mycobacterium kansasii.The drug resistance rates of the major species of non-tuberculous Mycobacteria to isoniazid,streptomycin,amikacin and aminosalicylic acid were 100.00％.CONCLUSION The non-tuberculous mycobacteriosis can be diagnosed in a timely manner by etiological culture,clinical symptoms,complications and imaging findings.M.intracellulare,Mycobacteria che-lonae subsp.abscessus,M.avium and M.kansasii are the predominant species of non-tuberculous Mycobacteria.It is necessary to carry out the targeted antibacterial treatment based on the result of drug susceptibility testing.
NETL
NSTL
万方数据
维普
