Predisposing factors for postoperative pulmonary infection and expressions of miR-31,miR-122 and miR-146a in lung caner patients undergoing thoracoscopic radical resection
OBJECTIVE To explore the predisposing factors for postoperative pulmonary infection in the lung cancer patients undergoing thoracoscopic radical resection and analyze the changes of relative expression levels of micro ri-bonucleic acid(miR-31),miR-122 and miR-146a.METHODS Totally 171 lung cancer patients who underwent the thoracoscopic radical resection in the People's Hospital of Jianyang City from Jan 2018 to Dec 2022 were recruited as the research subjects and were divided into the infection group with 34 cases and the non-infection group with 137 cases according to the status of postoperative pulmonary infection.The etiological characteristics,predispo-sing factors for the pulmonary infection and expression levels of peripheral blood miR-31,miR-122 and miR-146a were observed.RESULTS Among the 171 lung cancer patients who underwent the thoracoscopic radical resection,34 had postoperative pulmonary infection,with the incidence rate 19.88％.Totally 35 strains of pathogens were i-solated,27(77.14％)of which were gram-negative bacteria.The predisposing factors included more than 60 years of age,smoking history and diabetes mellitus(P＜0.05).The expression levels of peripheral blood miR-31 and miR-122 of the infection group were higher than those of the non-infection group,while the expression level of miR-146a of the infection group was lower than that of the non-infection group(P＜0.05).The area under curve(AUC)of the joint detection of the three indexes was 0.946 in diagnosis of the postoperative pulmonary infection,with the sensitivity 91.18％,the specificity 87.59％.CONCLUSION The incidence of pulmonary infection is high among the lung cancer patients undergoing thoracoscopic radical resection.The gram-negative bacteria are dominant among the pathogens.The predisposing factors include the more than 60 years of age,smoking his-tory and diabetes mellitus.The joint detection of miR-31,miR-122 and miR-146a may raise the diagnostic value.It is necessary for the hospital to take targeted prevention and treatment measures so as to reduce the risk of the disease.
Thoracoscopic radical resection for lung cancerPulmonary infectionEtiologymiR-31miR-122miR-146aPredisposing factorDiagnostic value
NETL
NSTL
万方数据
维普
