Risk factors for HBV infection in children after combined immunosuppression of mother-to-child transmission of hepatitis B virus and establishment of prediction model
OBJECTIVE To explore the risk factors for hepatitis B virus(HBV)infection in the children after com-bined immunosuppression of mother-to-child transmission of HBV and establish the prediction model.METHODS A total of 629 mothers with positive hepatitis B surface antigen(HBsAg)and their children who were treated in the Nantong First People's Hospital from Apr 2018 to Dec 2022 were recruited as the research subjects.25 chil-dren who had HBV infection after combined immunosuppression of mother-to-child transmission of HBV were as-signed as the study group,and 604 children who did not have HBV infection were set as the control group.Multi-variate logistic regression analysis was performed for the risk factors for the HBV infection in the children.The clinical value of the prediction model for HBV infection was analyzed by means of receiver operating characteristic(ROC)curves.RESULTS The age of mother at delivery no more than 28 years old and positive HBeAg of mother were independent risk factors for the HBV infection in the children after combined immunosuppression of mother-to-child transmission of HBV(P＜0.05).The regression model that was established based on the independent risk factors was as follows:Logit(P)=-10.986+age of mother at delivery no more than 28 years of age X0.859+positive HBeAg of motherX0.794,when Logit(P)was greater than 11,the area under curve(AUC)was 0.854 in prediction of the HBV infection in the children,with the sensitivity 88.00％,the specificity 69.54％.CONCLUSION The age of mother at de-livery no more than 28 years old and positive HBeAg of mother are the risk factors for the HBV infection in the children after combined immunosuppression of mother-to-child transmission of HBV.The model has high predictive value.It is necessary for the hospital to take targeted prevention measures so as to reduce the risk of HBV infection after combined immunosuppression of mother-to-child transmission of HBV.
Hepatitis B virusMother-to-child transmissionPositive hepatitis B surface antigenInfectionRisk factorPrediction model
NETL
NSTL
万方数据
维普
