Etiological characteristics of NEC in neonates with intestinal infection and early diagnostic values of serum PCT,hs-CRP and ENA-78
OBJECTIVE To explore the etiological characteristics of necrotizing enterocolitis(NEC)in the neonates with intestinal infection and observe the early diagnostic values of serum procalcitonin(PCT),high-sensitivity C-reactive protein(hs-CRP)and neutrophil activating peptide-78(ENA-78).METHODS A total of 80 neonates with intestinal infection who were treated in neonatology department of the Affiliated Maternity and Child Health Care Hospital of Nantong University from Feb 2019 to Feb 2021 were recruited as the research subjects and were divid-ed into the NEC group with 24 cases and the non-NEC group with 56 cases according to the status of complication with NEC.Meanwhile,40 hospitalized neonates who did not have intestinal infection were chosen as the control group.The etiological characteristics of the neonates in the NEC group were statistically analyzed,the levels of se-rum PCT,hs-CRP and ENA-78 were detected for the three groups of neo nates,and the clinical values of the three indexes in early diagnosis of NEC were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS Totally 35 strains of pathogens were isolated from the 24 neonates in the NEC group,57.14％of which were gram-negative bacteria.There were significant differences in the levels of serum PCT,hs-CRP and ENA-78 among the three groups(P＜0.05),and the levels of the above indexes of the NEC group were higher than those of the non-NEC group and the control group(P＜0.05).The result of ROC curve analysis showed that the serum PCT,hs-CRP and ENA-78 had high values in diagnosis of NEC,the areas under curves(AUCs)were 0.835,0.920 and 0.933,respectively;the joint detection of the three indexes had higher diagnostic value,with the AUC 0.955.CONCLUSION The gram-negative bacteria are dominant among the pathogens isolated from the intestinal infection neonates complicated with NEC.The joint detection of serum PCT,hs-CRP and ENA-78 has high value in early diagnosis of NEC.
NETL
NSTL
万方数据
维普
