Pathogenic bacteria isolated from neonates with peripherally inserted central venous catheter-associated bloodstream infection and influencing factors
OBJECTIVE To explore the distribution of pathogenic bacteria isolated from the neonates with peripher-ally inserted central venous catheter(PICC)-associated bloodstream infection and analyze the influencing factors.METHODS The clinical data were collected from the neonates who were treated with central venous catheterization by peripheral venous puncture in Hangzhou Lin'an District First People's Hospital and Hangzhou Children's Hos-pital from Jan 2018 to Jan 2023.The enrolled neonates were divided into the infection group with 34 cases and the non-infection group with 655 cases according to the status of catheter-associated bloodstream infection.The distri-bution of pathogens isolated from the neonates with PICC-associated bloodstream infection was observed.Univari-ate analysis and multivariate logistic regression analysis were performed for influencing factors for the infection.RESULTS Of the 689 neonates who were treated with PICC,34 had catheter-associated bloodstream infection,with the incidence of infection 4.93％.Totally 34 strains of pathogens were isolated,11(32.35％)of which were gram-negative bacteria,20(58.82％)were gram-positive bacteria,and 3(8.82％)were fungi.The results of multivariate logistic a-nalysis showed that birth weight no more than 1500g,catheter indwelling duration more than 14 days and 5 min Apgar score no more than 7 points were the influencing factors for the PICC-associated bloodstream infection in the neonates(P＜0.05).CONCLUSION The incidence of PICC-associated bloodstream infection is high among the neonates.The gram-positive bacteria are dominant among the pathogens causing the infection.The incidence of PICC-associated blood-stream infection is closely associated with the birth weight,catheter indwelling duration and 5 min Apgar score.It is nec-essary for the hospital to take targeted prevention measures based on the influencing factors in early stage.
Peripherally inserted central venous catheterNeonateCatheter-associated bloodstream infectionPathogenInfluencing factor
NETL
NSTL
万方数据
维普
