首页|儿童反复呼吸道感染的危险因素及MCP-1、miR-146a和miR-155的预测价值

儿童反复呼吸道感染的危险因素及MCP-1、miR-146a和miR-155的预测价值

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目的 分析儿童反复呼吸道感染的危险因素及单核细胞趋化蛋白-1(MCP-1)、微小核糖核酸(miR)-146a和miR-155的预测价值。方法 选取2020年1月-2022年7月长江大学附属仙桃市第一人民医院收治的呼吸道感染患儿204例纳入研究，其中67例反复呼吸道感染患儿为研究组，其余137例偶发或不符合反复呼吸道感染标准的患儿为对照组，归纳儿童反复呼吸道感染的危险因素，绘制受试者工作特征(ROC)曲线分析MCP-1、miR-146a和miR-155检测对儿童反复呼吸道感染的预测价值。结果 呼吸道感染患儿204例中反复呼吸道感染患儿共67例，占比为32。84％;多因素Logistic分析结果显示，母乳喂养＜6个月、每天户外活动时间＜1。5 h、被动烟草暴露、近一年装修、偏食是儿童反复呼吸道感染的危险因素(P＜0。05);与对照组比较，研究组MCP-1、miR-146a和miR-155表达水平升高(P＜0。05);ROC曲线分析结果显示，MCP-1、miR-146a和miR-155联合检测预测儿童反复呼吸道感染的临床价值较高，曲线下面积(AUC)为0。902。结论 儿童反复呼吸道感染的危险因素较多，MCP-1、miR-146a、miR-155联合检测对儿童反复呼吸道感染预测价值高，可作为临床诊治的新靶点。
Risk factors for recurrent respiratory tract infection in children and predictive values of MCP-1,miR-146a and miR-155
OBJECTIVE To analyze the risk factors for recurrent respiratory tract infection in the children and ob-serve the predictive values of monocyte chemoattractant protein-1(MCP-1),micro ribonucleic acid(miR)-146a and miR-155.METHODS A total of 204 children with respiratory tract infection who were treated in Xiantao First People's Hospital Affiliated to Changjiang University from Jan 2020 to Jul 2022 were enrolled in the study,67 of whom had recurrent respiratory tract infection and were assigned as the study group,the rest of 137 children who had the occasional infection or did not meet the diagnostic criteria for recurrent respiratory tract infection were as-signed as the control group.The risk factors for the recurrent respiratory tract infection were concluded.The val-ues of MCP-1,miR-146a and miR-155 in prediction of the recurrent respiratory tract infection were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS Among the 204 children with respiratory tract infection,67 had recurrent respiratory tract infection,accounting for 32.84％.The result of multivariate logistic analysis showed that less than 6 months of breast feeding,less than 1.5 hours of outdoor activity per day,passive exposure to tobacco,house decoration time less than 1 year and ill-balanced diet were the risk factors for the recur-rent respiratory tract infection in the children(P＜0.05).The expression levels of MCP-1,miR-146a and miR-155 of the study group were higher than those of the control group(P＜0.05).ROC curve analysis showed that the joint detection of MCP-1,miR-146a and miR-155 had high clinical value in prediction of recurrent respiratory tract infection,with the area under curve(AUC)0.902.CONCLUSION There are a variety of risk factors for the re-current respiratory tract infection in the children.The joint detection of MCP-1,Mir-146a and miR-155 has high clinical value in prediction of the recurrent respiratory tract infection,which can be used as a new target for clinical diagnosis and treatment.

Recurrent respiratory tract infectionChildMonocyte chemoattractant protein-1Micro ribonucleic acid-146aMicro ribonucleic acid-155Risk factorPredictive value

易贤红、马玲、杜鑫、冯玲玲、邹慧

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长江大学附属仙桃市第一人民医院儿科,湖北仙桃 433000

反复呼吸道感染 儿童 单核细胞趋化蛋白-1 微小核糖核酸-146a 微小核糖核酸-155 危险因素 预测价值

湖北省卫生和计划生育委员会科研项目

WJ2017F127

2024

10.11816/cn.ni.2024-230164

中华医院感染学杂志
中华预防医学会 中国人民解放军总医院

中华医院感染学杂志

CSTPCD北大核心
影响因子：1.885
ISSN：1005-4529
年,卷(期)：2024.34(1)
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