Progress of research on treatment of sepsis-induced acute lung injury
Sepsis often arises as a secondary condition following trauma,burns,infections,shock,and other conditions.Untimely intervention can lead to the progression of sepsis into multi-organ failure and eventual mortality.Sepsis triggers a significant activation of macrophages in the lungs,resulting in the release of a plethora of inflammatory factors that con-tribute to the development of acute lung injury(ALI).In severe cases,ALI can further advance to acute respiratory dis-tress syndrome(ARDS),which is a grave complication associated with sepsis and carries a high morbidity and mortality rate.ALI/ARDS induces diffuse damage to alveolar epithelial cells and pulmonary capillary endothelial cells,leading to an increase in alveolar capillary permeability and subsequent pulmonary edema.Clinical manifestations of ALI/ARDS include refractory hypoxemia and fatal respiratory failure.Currently,no reliable biomarkers or predictive methods are available for anticipating the occurrence and progression of ALI/ARDS,and supportive treatment is taken as the major clinical treat-ment approach.This review article aims to summarize the latest advancements in understanding the pathogenesis and ther-apeutic approaches for sepsis-associated lung injury.
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维普
