Clinical effect of Liangge Baihu decoction add and subtract on treatment of severe pneumonia and changes of expressions of HMGB1,sTREM-1 and IFN-γ
OBJECTIVE To observe the effect of Liangge Baihu decoction add and subtract on treatment of severe pneumonia and analyze the changes of expression levels of high mobility group protein B1(HMGB1),soluble trig-gering receptor expressed on myeloid cells(sTREM-1)and interferon-γ(IFN-γ).METHODS A total of 80 pa-tients with severe pneumonia who were treated in Jianmusi Traditional Chinese Medicine Hospital from Jan 2021 to Jan 2023 were enrolled in the study and randomly divided into the control group and the experimental group,with 40 cases in each group.The control group was given intravenous drip of ambroxol hydrochloride injection for expectoration on basis of routine symptomatic and supportive western medicine treatment,while the experimental group was treated with Liangge Baihu decoction add and subtract for expectoration.Both groups were treated for 14 days.The curative effect and the levels of HMGB1,sTREM-1 and IFN-γ were observed and compared between the two groups.RESULTS After the treatment for 14 days,the effective rate of treatment was 92.50％in the ex-perimental group,72.50％in the control group,and there was significant difference(x2=5.541,P=0.019).The scores of TCM syndromes(fever,cough,shortness of breath,phlegm obstruction)of the experimental group were lower than those of the control group(P＜0.05).The respiratory function indexes[forced vital capacity(FVC),maximal mid-expiratory flow(MMF),peak expiratory flow(PEF)]of the experimental group were su-perior to those of the control group(P＜0.05).The levels of immune function indexes CD3+,CD4+ and CD8+ of the experimental group were superior to those of the control group(P＜0.05).The levels of inflammatory indexes HMGB1,sTREM-1 and IFN-y of the experimental group were lower than those of the control group(P＜0.05).CONCLUSION Liangge Baihu decoction add and subtract can achieve exact effect on treatment of severe pneumoni-a,improve the score of TCM syndrome,reduce the levels of serum HMGB1,sTREM-1 and IFN-y,improve the respiratory function,and regulate the immune function.
Liangge Baihu decoction add and subtractSevere pneumoniaRespiratory functionHigh mobility group protein B1Soluble triggering receptor expressed on myeloid cell-1Interferon-γTCM syndrom score
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