幽门螺杆菌感染相关胃癌化疗患者症状群特征
Symptom cluster characteristics of Helicobacter pylori-related gastric cancer patients undergoing chemotherapy
樊丽媛 1李梦鸽 2何义富 2丁从兰 2毕清泉3
作者信息
- 1. 安徽医科大学护理学院,安徽合肥 230601;中国科学技术大学附属第一医院(安徽省立医院)西区肿瘤内科一病区,安徽合肥 230031
- 2. 中国科学技术大学附属第一医院(安徽省立医院)西区肿瘤内科一病区,安徽合肥 230031
- 3. 安徽医科大学护理学院,安徽合肥 230601
- 折叠
摘要
目的 探讨幽门螺杆菌(Hp)感染相关胃癌化疗患者症状群的内部特征及其影响因素.方法 采用横断面调查,于2021年12月-2022年5月选取中国科学技术大学附属第一医院西区收治的211例胃癌患者为研究对象,收集患者化疗期间疲乏、疼痛、食欲不振、睡眠障碍、焦虑、抑郁症状,使用潜在类别模型分组,多分类Logis-tic回归分析其影响因素.结果 Hp感染相关胃癌化疗患者症状群表现为4种不同的类别,分别命名为"低症状组"、"高症状组"、"低心理症状组"和"高心理症状组",占比依次为27.4％、19.0％、43.1％和10.4％;多分类Lo-gistic 回归分析显示,无吸烟史(OR=0.283,P=0.013)是"低心理症状组"的保护因素,无饮酒史(OR=10.852,P=0.011)是"高心理症状组"的危险因素.结论 Hp感染相关胃癌患者化疗期间的症状群存在明显不同的分类特征,需要根据不同类别患者的症状特征,给予个性化管理和干预.
Abstract
OBJECTIVE To explore the internal characteristics of symptom cluster of gastric cancer patients with Helicobacter pylori infection and analyze the influencing factors.METHODS By means of cross-sectional survey,to-tally 211 gastric cancer patients who were treated in west campus of the First Affiliated Hospital of USTC from Dec 2021 to May 2022 were recruited as the research subjects.The patients who had fatigue,pain,loss of appetite,sleep disturb-ance,anxiety and depression during the chemotherapy were collected and grouped based on latent class model.Multivari-ate logistic regression analysis was performed for the influencing factors.RESULTS The symptom cluster manifestations of the patients with H.pylori infection-related gastric cancer were identified as 4 classes and were named as'low symp-tom burden class','high symptom burden class','low psychological class'and'high psychological class',respectively;the four classes accounted for 27.4％,19.0％,43.1％and 10.4％,respectively.The result of multivariate logistic re-gression analysis showed that no history of smoking(OR=0.283,P=0.013)was the protective factor for the'low psy-chological class',and no history of alcohol drinking(OR=10.852,P=0.011)was the risk factor for the'high psycho-logical class'.CONCLUSION There are significant classifying features for the symptom cluster of the patients with H.pylori infection-related gastric cancer during the chemotherapy.It is necessary to formulate individualized management and intervention plans for the patients based on the symptom characteristics.
关键词
幽门螺杆菌感染/胃癌/化疗期/症状群/潜在类别分析/问卷调查Key words
Helicobacter pylori infection/Gastric cancer/Chemotherapy/Symptom cluster/Latent class analy-sis/Questionaire survey引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据