Influence of HPV infection on vaginal microflora,expressions of miR-21,COX-2 and inflammatory factors in patients with chronic cervicitis
OBJECTIVE To observe the influence of human papillomavirus(HPV)infection on vaginal microflora,expressions of micro ribonucleic acid(miR-21),cyclooxygenase-2(COX-2)and inflammatory factors in the pa-tients with chronic cervicitis.METHODS Totally 204 chronic cervicitis with HPV infection and 210 chronic cervi-citis patients without HPV infection who were treated in the Tianjin Fifth Central Hospital from Jun 2019 to Feb 2023 were enrolled in the study and were respectively assigned as the HPV-positive group and the HPV-negative group.The vaginal microflora and levels of miR-21,COX-2 and inflammatory factors were observed and com-pared between the two groups.RESULTS The proportions of patients with Mycoplasma vaginalis,trichomoniasis and mycotic infections were in the HPV-positive group than in the HPV-negative group(P＜0.05).The levels of miR-21,COX-2,interleukin(IL)-4 and tumor necrosis factor-α(TNF-α)of the HPV-positive group were higher than those of the HPV-negative group;while the levels of IL-2 and interferon-γ(IFN-γ)of the HPV-positive group were lower than those of the HPV-negative group(P＜0.05).The levels of miR-21,COX-2 and IL-4 of the patients with high-risk HPV infection were higher than those of the patients with low-risk HPV infection,while the levels of IL-2 and IFN-γ of the patients with high-risk HPV infection were lower than those of the patients with low-risk HPV infection(P＜0.05).The levels of miR-21,COX-2 and IL-4 of the patients with vaginal dys-bacteriosis were higher than those of the patients with normal vaginal microflora;while the levels of IL-2 and IFN-y of the patients with vaginal dysbacteriosis were lower than those of the patients with normal vaginal microflora(P＜0.05).CONCLUSION The HPV infection may result in the disorder of vaginal microflora in the patients with chronic cervicitis and affect the levels of miR-21,COX-2 and inflammatory factors.The high-risk HPV in-fection and vaginal dysbacteriosis may also lead to the abnormal changes of miR-21.COX-2 and inflammatory fac-tors of the chronic cervicitis patients with HPV infection.
NETL
NSTL
万方数据
维普
