Clinical effect of paclitaxel combined with cisplatin on treatment of cervical cancer
OBJECTIVE To observe the clinical effect of paclitaxel combined with cisplatin(TP)on treatment of the patients with cervical cancer.METHODS Totally 62 patients with cervical cancer who were treated in the First People's Hospital of Zunyi City from May 2021 to May 2022 were recruited as the study subjects and were divided into the group A(paclitaxel plus carboplatin)and the group B(paclitaxel plus cisplatin)according to chemothera-py regimens,with 31 cases in each group.The clinical effect was compared between the two groups by comparing the effective rate of treatment,incidence of adverse reactions,(WHOQOL-BREF score,levels of tumor markers)before and after treatment and KPS score(before treatment,7 days,1 month,2 months and 3 months after treat-ment).RESULTS The effective rate of treatment was 74.19％in the group A,93.55％in the group B,and there was significant difference(x2=4.292,P=0.038).The total incidence of adverse reactions was 80.65％in the group A,54.84％in the group,and there was significant difference(x2=4.723,P=0.029).There was no sig-nificant difference in the WHOQOL-BREF score between the two groups before the treatment,the score of the two groups was higher after the treatment than before the treatment(P＜0.05),and the score of the group B was higher than that of the group A(P＜0.05).There was no significant difference in the KPS score between the two groups before the treatment,and the KPS score of the group B was higher than that of the group A after the treat-ment for 7 days,1 month,2 months and 3 months(P＜0.05).There were no significant differences in the levels of tumor markers between the two groups before the treatment,the levels of tumor markers of the two groups were lower after the treatment than before the treatment(P＜0.05),and the levels of the tumor markers of the group B were lower than those of the group A(P＜0.05).CONCLUSION The TP regimen can effectively improve the levels of tumor markers of the cervical cancer patients during chemotherapy and raise the quality of life,it is safe and highly effective.
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