Distribution and drug resistance of pathogens isolated from neonates with bloodstream infection
OBJECTIVE To observe the distribution and drug susceptibility of the pathogens isolated from the neo-nates with bloodstream infection so as to provide objective bases for clinical diagnosis,reasonable use of antibiotics and raise the cure rate.METHODS The clinical dada were collected from the neonates who were positive for blood culture in Ningbo Women and Children's Hospital from Jun 2019 to Mar 2022 and were retrospectively analyzed.The distribution of the pathogens and the drug resistance rates to commonly used antibiotics were observed.RESULTS A total of 251 neonates were positive for culture of blood specimens,dominated by the preterm neonates,neo-nates of intensive care unit,neonates with late-onset sepsis and male neonates.Totally 251 strains of pathogens were iso-lated from the blood specimens,41(16.33％)of which were gram-negative bacteria,207(82.47％)were gram-positive bacteria,and 3(1.20％)were fungi.Staphylococcus epidermidis(74 strains,29.48％),Staphylococcus aureus(28 strains,11.16％)and Staphylococcus warneri(21 strains,8.37％)ranked the top 3 places among the isolated patho-gens.The drug resistance rate of the gram-positive bacteria to penicillin was 71.98％,no strain was found resistant to vancomycin,and the drug resistance rates to the commonly used antibiotics were high.The drug resistance rate of the gram-negative bacteria to ampicillin was 21.95％,no imipenem-resistant strain was found,and the drug resistance rates to the commonly used cephalosporins were high.CONCLUSION The pathogens isolated from the neonates with sep-sis vary in the onset time and gestational age.It is necessary to strengthen the surveillance of pathogens and rea-sonably use antibiotics based on the result of drug susceptibility testing.
NETL
NSTL
万方数据
维普
