Pathogenic bacteria and PCT,IL-16 and TGF-β level in radiation pneumonia with lung infection after radiotherapy for lung cancer
OBJECTIVE To analyze the pathogenic bacteria and levels of serum procalcitonin(PCT),interleukin-16(IL-16)and transforming growth factor-β(TGF-β)in patients with radiation pneumonia and lung infection after radiotherapy for lung cancer.METHODS Totally 108 patients with radiation pneumonia and lung infection after ra-diotherapy for lung cancer who were admitted to Xinxiang Central Hospital from Mar.2020 to Dec.2022 were se-lected as the study group.According to the severity of pneumonia,the patients in study group were classified into grade 1 group(n=17),grade 2 group(n=56)and grade 3-4 group(n=35),and 148 patients with lung cancer who were treated during the same period were selected as the control group.The pathogenic bacteria of patients in study group were analyzed,and serum levels of PCT,IL-16 and TGF-β were compared in each group.The predic-tive value of serum PCT,IL-16 and TGF-β on radiation pneumonia with lung infection after radiotherapy for lung cancer was evaluated by receiver operating characteristic(ROC)curve.RESULTS A total of 129 strains of patho-genic bacteria were detected in 108 patients with radiation pneumonia and lung infection after radiotherapy for lung cancer,of which 72 strains of gram-negative bacteria accounted for 55.81％,50 strains of gram-positive bacteria accounted for 38.76％,and 7 strains of fungi accounted for 5.43％,mainly Klebsiella pneumoniae,Staphylococ-cus aureus and Escherichia coli.The levels of PCT,IL-16 and TGF-β in the study group were higher than those in the control group(P＜0.05).Serum levels of PCT,IL-16 and TGF-β in the grade 3-4 group were higher than those in the grade 1 and the grade 2 groups(P＜0.05),and the above levels in grade 2 group were higher than those in grade 1 group(P＜0.05).The areas under the curves of PCT,IL-16,TGF-β and their combination of the three in predicting radiation pneumonia with lung infection after radiotherapy for lung cancer were 0.928,0.888,0.886 and 0.965 respectively.CONCLUSION The pathogenic bacteria in patients with radiation pneumonia and lung infection after radiotherapy for lung cancer were mainly gram-negative bacteria,and levels of PCT,IL-16 and TGF-β were significantly increased,and the combined detection of the three was conductive to improving the pre-dictive value of radiation pneumonia with lung infection after radiotherapy for lung cancer.
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