Expressions of CHI3L1 and NEAT1 in gastric cancer tissues and association with HBV infection
OBJECTIVE To investigate the expression of chitosanase 3-like protein 1(CHI3L1)and nuclear enriched transcript 1(NEAT1)in gastric cancer tissues and their relationship with hepatitis B virus(HBV)infection.METHODS Clinical data of 202 patients with gastric cancer who underwent examined at the Endoscopy Center of Qijiang District People's Hospital of Chongqing from Jun.2018 to Mar.2023 were retrospectively selected,and the gastric cancer tissues and adjacent tissues were collected and divided into gastric cancer group(n=202)and adjacent cancer group(n=202),which were divided into HBV(+)and HBV(-)according to whether they were infected with HBV.The expression of CHI3L1,NEAT1 and HBV infection in gastric cancer group and para-cancer group,as well as and the relationship between the expression of CHI3L1 and NEAT1 and clinicopathologi-cal parameters of gastric cancer patients was compared.The correlation between the expression of CHI3L1 and NEAT1 in gastric cancer tissues and HBV infection was analyzed.RESULTS The positive expression rates of CHI3L1 and NEAT1 in the gastric cancer group were higher than those in the adjacent cancer group(P＜0.05).In gastric cancer group,the positive expression rate of CHI3L1 and NEAT1 in HBV-positive patients was higher than that in HBV-negative patients(P＜0.05).Among patients with different TNM stages in the gastric cancer group,the positive expression rate of NEAT1 was higher in patients with stage Ⅲ to Ⅳ than in patients with stage Ⅰ to Ⅱ(P＜0.05).The positive expression rates of CHI3L1 and NEAT1 in patients with lymph node me-tastasis were higher than those without lymph node metastasis(P＜0.05).In the degree of differentiation,the positive expression rate of CHI3L1 in low-differentiation was significantly lower than that in middle and high dif-ferentiation(P＜0.05).In the depth of tumor invasion,the positive expression rates of CHI3L1 and NEAT1 in the invasion of the plasma membrane and outer plasma layer were higher than those in the invasion of the mucosa and muscle(P＜0.05).The expression of CHI3L1 and NEAT1 in gastric cancer group was positively correlated with HBV infection(r=0.431,0.479,P＜0.05).CONCLUSION The expression of CHI3L1 and NEAT1 was highly expressed in cancer tissues of gastric cancer patients,and the expression of CHI3L1 might be related to lymph node metastasis,differentiation degree,and depth of tumor invasion,while the expression of NEAT1 might be related to tumor TNM stage,lymph node metastasis,and depth of tumor invasion.The positive expres-sion of CHI3L1 and NEAT1 in the tissues of gastric cancer was positively correlated with HBV infection.
Chitinase-3-like protein 1Nuclear-enriched abundant transcript 1Gastric cancerInfectionHepati-tis B virusClinicopathology
NETL
NSTL
万方数据
