Pathogenic bacteria and VDR gene diversity in ascites of patients with secondary nosocomial infection of acute pancreatitis and its relationship with prognosis
OBJECTIVE To investigate pathogenic bacteria and vitamin D receptor(VDR)gene diversity in ascites of patients with secondary hospital infection of acute pancreatitis and its relationship with prognosis.METHODS The clinical data of 258 patients with secondary nocomial infection of acute pancreatitis admitted to Jingzhou Hos-pital Affiliated to Yangtze University and Xiangyang Central Hospital from Jan.2019 to Jan.2023 were retrospec-tively collected,and the patients were divided into the good prognosis group(205 cases)and the poor prognosis group(53 cases)according to the prognosis of the patients.The pathogenic bacteria of ascites and the gene distri-bution of VDR FokI locus in patients with secondary nosocomial infection of acute pancreatitis were measured,and the influencing factors of poor prognosis in patients with secondary nosocomial infection of acute pancreatitis were analyzed.RESULTS A total of 269 strains of pathogenic bacteria were detected in ascites samples of 258 patients with secondary nosocomial infection of acute pancreatitis.The main pathogenic bacteria included Klebsiella pneu-moniae,Enterobacter cloacae,Staphylococcus aureus,Enterococcus faecium.The proportion of VDR FokI CC genotype of patients in poor prognosis group was lower than that in good prognosis group,while the proportion of TT genotype was higher than that in good prognosis group(P＜0.05).Multivariate logistic regression analysis showed that TT genotype of VDR FokI locus,number of organ disorders,bladder pressure,shock and serum tri-glyceride(TG)were risk factors for poor prognosis in patients with secondary nosocomial infection of acute pan-creatitis(P＜0.05).CONCLUSION The main pathogenic bacteria in patients with secondary nosocomial infection of acute pancreatitis were Klebsiella pneumoniae,Enterobacter cloacae,Staphylococcus aureus,Enterococcus faecium,and there were many main risk factors for poor prognosis.Therefore,targeted treatment or intervention could be implemented for patients with related symptoms or characteristics to improve the prognosis of patients.
Acute pancreatitisHospital infectionAscitesPathogenic bacteriologyVitamin D receptorGenetic diversityPrognosisRisk factor
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