Pathogenic bacteria and conjugate globin gene polymorphisms in reproductive tract infection of pregnant women with premature rupture of fetal membrane and their impacts on maternal and infant outcomes
OBJECTIVE To analyze the pathogenic bacteria and conjugate globin gene polymorphisms of reproduc-tive tract infection in pregnant women with premature rupture of fetal membrane and their effects on maternal and infant outcomes.METHODS A total of 120 pregnant women with premature rupture of membranes who were com-plicated with reproductive tract infection and treated in Qingdao Hospital of Traditional Chinese Medicine from Apr.2020 to Jan.2023 were selected as the study group,and another 132 pregnant women with premature rupture of membranes who were not complicated with reproductive tract infection were selected as the control group.Clini-cal data of pregnant women were retrospectively collected.The etiology and binding globin gene polymorphisms in maternal combined reproductive tract infections premature rupture of fetal membrane,and maternal and infant outcomes were analyzed.RESULTS The maternal combined reproductive tract infections with premature rupture of membranes were dominated by Mycoplasma urealyticum(30.00％),group B Streptococcus(12.50％)and Can-dida(10.00％),and the mixed infections(20.00％)were more common.The proportion of binding globin gene Hp2-2 genotype in study group was higher than that in control group(P＜0.05).The incidence of intrauterine in-fection,postpartum hemorrhage,chorioamnionitis,cesarean section,fetal distress,neonatal asphyxia and neo-natal infection in the study group was higher than that in the control group(P＜0.05).CONCLUSION The highest percentage of pathogenic bacteria for reproductive tract infection in pregnant women with premature rupture of fe-tal membrane was Ureaplasma urealyticum,and mixed infection was more common.Pregnant women with the Hp2-2 genotype of the binding bead protein gene were susceptible,and can influence maternal and infant out-comes.
Premature rupture of membranesPuerperaGenital tract infectionPathogenic bacteriaHaptoglo-binGene polymorphismMaternal and infant outcome
NETL
NSTL
万方数据
