Values of infection markers and lymphocyte subsets at early stage of admission in prediction of bacterial pneumonia in children
OBJECTIVE To compare and analyze the predictive value of early infection markers and lymphocyte sub-sets on admission in children with bacterial pneumonia.METHODS Totally 104 children with bacterial community-acquired pneumonia(CAP)admitted to the pediatric department of the First Affiliated Hospital of Hainan Medical College from Mar.2021 to Mar.2023 were selected as the study group,and were divided into a severe group(48 cases)and a general group(56 cases)according to regression of their conditions during the subsequent hospitaliza-tion,and 110 children who underwent health examinations during the same period were selected as the control group.The white blood cell count(WBC),neutrophil count(NEU),erythrocyte sedimentation rate(ESR),CD4+T lymphocyte percentage,CD8+T lymphocyte percentage,CD4+/CD8+T lymphocyte ratio in peripheral blood,and the serum levels of procalcitonin(PCT)and C-reactive protein(CRP)of children in each group were detected.RESULTS The infection markers in the severe group and the general group were all higher than those in the control group,while CD4+T lymphocyte percentage,CD8+T lymphocyte percentage,CD4+/CD8+T lympho-cyte ratio were all lower than those in the control group.The PCT and CRP levels in the severe group were higher than those in the general group,while CD4+T lymphocyte percentage and CD4+/CD8+T lymphocyte ratio were all lower than those in the general group(P＜0.05).The areas under the receiver operating characteristic curve(AUC)for PCT,CRP,CD4+T lymphocyte percentage and CD4+/CD8+T lymphocyte ratio to predict the severi-ty of bacterial pneumonia in children was statistically significant(P＜0.05),of which the AUC of CD4+/CD8+T lymphocyte ratio was the highest,followed by PCT,with CD4+/CD8+T lymphocyte ratio having the highest sen-sitivity and CRP having the highest specificity.CONCLUSION Compared with children with common bacterial CAP,children with severe CAP exhibited abnormalities in infection markers such as PCT and CRP,as well as T lymphocyte subgroups in the early stages of hospitalization,and the detection of the above indexes could be used as a reference for predicting the severity of the children.
Infection markerT lymphocyte subsetBacterial pneumoia in childSeverity predictionProcalcitoninC-reac-tive proteinWhite blood cellNeutrophilsErythrocyte sedimentation rateCommunity-acquired pneumonia in child
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