Influencing factors for direct economic loss due to nosocomial infection in premature infants
OBJECTIVE To analyze the factors influencing the direct economic loss of nosocomial infection in prema-ture infants.METHODS Data on premature infants in the Neonatal Intensive Care Unit of the First Hospital of Quanzhou City from Jan.1,2018 to Dec.31,2022 were retrospectively collected,and recursive system modeling was used to analyze the impact of each factors on the direct economic loss of nosocomial infection in premature in-fants.RESULTS A total of 1 205 cases of premature infants were included,124 patients had nosocomial infection,with an infection rate of 10.29％.A total of 121 pairs were successfully matched by the propensity score matching method.The median hospitalization days of preterm infants in the nosocomial infection group and non-hospital in-fection group were 34 and 7 days,respectively,with the nosocomial infection group having a longer hospitalization time of 27 days compared with the non-hospital infection group(P＜0.001).The median of hospitalization cost of the nosocomial infection group was 39 636.94 yuan and 8 982.02 yuan in the non-hospital infection group,and the hospitalization cost in the nosocomial infection group was 30 654.92 yuan more than that in the non-hospital infec-tion group(P＜0.001).Among the increased costs,the costs of medicines,treatments,and examinations were the main sources of costs.Birth weight had both a direct and an indirect effect on the direct economic loss of noso-comial infection in premature infants,with the greatest impact.The index such as hospitalization days,gastric tube retention and tracheal intubation had only a direct effect,while the index such as gestational age and the num-ber of days of antimicrobial drug use had only an indirect effect on economic losses of nosocomial infection in pre-mature infants.CONCLUSION In clinical practice,it is necessary to focus on premature infants with birth weight mass＜1 500 g and gestational age＜32 weeks,shorten the number of hospitalization days as much as possible,reduce invasive procedures,and control the days of antimicrobial drug use,so as to control the cost of hospitaliza-tion and to reduce the economic burden of the infants.
Premature infantsNosocomial infectionDirect economic lossesRecursive system modelInfluen-cing factorEffect
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