Effect of oral administration of alcohol extract of yellow milk tree stems on JAKSTAT signaling pathway of lupus nephritis patients complicated with urinary tract infection
OBJECTIVE To analyze the effects of alcohol extract of yellow milk tree stems on Janus kinase signal transductor and activator of transcription pathway(JAKSTAT)signaling pathway in patients with lupus nephritis complicated with urinary tract infection.METHODS A total of 45 patients with lupus nephritis and urinary tract infection who were diagnosed and treated at the West China Hospital of Sichuan University from Jun.2022 to Jun.2023 were selected as the study subjects,and were divided into the model group,the low-dose group and the high-dose group,with 15 cases in each group,and 30 healthy patients who underwent physical examination in the hospital during the same period were selected as the control group.The control and model groups were not trea-ted,and the low-dose and high-dose groups were given 15 g and 30 g of alcohol extract of of yellow milk tree stems,respectively.The SLE activity index(SLEDAI)score,24h urinary protein,urinary tract infection with different factors,urinary culture results,serum creatinine(Scr),complement C3(C3),C4,erythrocyte deposi-tion rate(ESR),procalcitonin(PCT),hypersensitive C-reactive protein(hs-CRP),and white blood cells(WBC),interleukin-12(IL-12),transforming growth factor β1(TGF-β1),interleukin-6(IL-6)levels were ob-served.RESULTS Escherichia coli was the main pathogen detected in 45 cases of urinary tract infection.Com-pared with the control group,Scr,ESR,PCT,hs-CRP,WBC,IL-12,TGF-β1 and IL-6 were elevated in the model,low-dose and high-dose groups,while C3 and C4 were decreased(P＜0.05).Compared with the model group,Scr,ESR,PCT,hs-CRP,WBC,IL-12,TGF-β1 and IL-6 in low-dose and high-dose groups were de-creased,while C3 and C4 were increased(P＜0.05).Compared with the low-dose group,the levels of Scr,ESR,PCT,hs-CRP,WBC,IL-12,TGF-β1 and IL-6 in high-dose group were decreased,while C3 and C4 were in-creased(P＜0.05).CONCLUSION The alcoholic extract of yellow milk tree stem was known to inhibit inflamma-tory factors,balance immune function,as well as improve the prevention of urinary tract infection by modulating theJAKSTAT signaling pathway.
Alcohol extract of yellow milk tree stemsOral administrationJAKSTAT signal pathLupus nephri-tisUrinary tract infection
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