Risk factors for pulmonary infection during radiotherapy for head and neck tumors and the predictive value of the D-D,PCT and CRP levels
OBJECTIVE To explore the risk factors for pulmonary infection during radiotherapy for head and neck tumors and the predictive value of serum levels of D-dimer(D-D),procalcitonin(PCT),C-reactive protein(CRP).METHODS Totally 610 patients with head and neck tumors admitted to the Fourth Hospital of Hebei Medical Uni-versity from Jan.2018 to Dec.2022 were selected as the study subjects.and they were divided into a study group(combined with pulmonary infection,31 cases)and a control group(not combined with pulmonary infection,579 cases)according to pulmonary infection during the radiotherapy period.The serum levels of D-D,PCT,and CRP of the two groups were measured and the predictive value were analyzed,and the risk factors for pulmonary infec-tion combined with radiotherapy in patients with head and neck tumors;the predictive value of each index of pul-monary infection during radiotherapy for head and neck tumors were analyzed by the reveiver operating character-istics(ROC)curves.RESULTS The average levels of serum CRP,PCT,and D-D water in the study group were significantly higher than those in the control group;The results of multivariate logistic regression analysis indica-ted that age,invasive procedures and combined chemotherapy were independent risk factors affecting the occur-rence of lung infection in patients with head and neck tumors during radiotherapy.Serum CRP,PCT and D-D all had high predictive value for pulmonary infection,and the combination of all three tests had the highest predictive value.CONCLUSION Age,invasive procedures,and concurrent chemotherapy in patients with head and neck tumors were risk factors for concurrent lung infection in the patients undergoing radiotherapy;serum CRP,PCT,and D-D levels could effectively predict pulmonary infection in patients with head and neck tumors.
Head and neck tumorsRadiochemotherapyPulmonary infectionPathgenRisk factorD-dimerCalcitoninC-reactive protein
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