Relationship between EBV infection and the progression of nasopharyngeal carcinoma and the diagnostic value of its associated antibodies
OBJECTIVE To investigate the relationship between EB virus(EBV)infection and the progression of nasopharyngeal carcinoma and the diagnostic value of its associated antibodies.METHODS Totally 103 patients with nasopharyngeal carcinoma admitted to Wuhan University of Technology Hospital from Jan.2021 to Mar.2023 were selected as the nasopharyngeal carcinoma group,and 112 healthy individuals underwent physical exami-nation during the same period were selected as the control group;the levels of serum EBV-DNA,early antigen immunoglobulin A antibody(EA IgA),capsid antigen(VCA)IgA,and Rta protein(Rta)IgG between two groups were compared,the diagnostic value of serum EBV-DNA,EA IgA,VCA IgA,and Rta IgG for nasopha-ryngeal carcinoma was analyzed by plotting the receiver operating characteristic(ROC)curve,and the risk factors for the occurrence of nasopharyngeal carcinoma were summarized by multivariate Logistic regression.RESULTS The serum levels of EBV-DNA,EA-IgA,VCA-IgA,and Rta-IgG in the nasopharyngeal carcinoma group were higher than those in the control group(P＜0.05).The serum levels of EBV-DNA,EA-IgA,VCA-IgA,and Rta-IgG in the stage Ⅲ-Ⅳ group were higher than those in the stage Ⅰ-Ⅱ group(P＜0.05).The area under the curve(AUC)value for the combined diagnosis of nasopharyngeal carcinoma by serum EBV-DNA,EA-IgA,VCA-IgA,and Rta-IgG was 0.929,which was higher than that of EBV-DNA with EA-IgA,VCA-IgA,and Rta-IgG alone(0.866,0.849,0.832,0.856,P＜0.05).The results of multivariate Logistic regression analysis showed that EBV-DNA,EA IgA,VCA IgA,and Rta IgG were independent risk factors for the occurrence of na-sopharyngeal carcinoma(OR=4.768,2.596,3.013,2.992,all P＜0.05).CONCLUSION The occurrence of na-sopharyngeal carcinoma was associated with serum levels of EBV-DNA,EA-IgA,VCA-IgA,and Rta-IgG,all four could be involved in the progress of the patient's condition,and the combined detection of the four had higher diagnostic value for nasopharyngeal carcinoma.
Nasopharyngeal cancerEB virusInfectionAntibodiesDisease progressionDiagnostic value
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