Effects of EBV infection on coronary artery disease and TIMP-1,NF-κB and IκBa in children with Kawasaki disease
OBJECTIVE To investigate the effects of Epstein Barr virus(EBV)infection on coronary artery disease,and matrix metalloproteinase inhibitor-1(TIMP-1),nuclear factor-κB(NF-κB),and nuclear factor-κB inhibitory protein(IκBα)in children with Kawasaki disease.METHODS A total of 136 children with Kawasaki disease ad-mitted to Xinxiang Central Hospital from Jun.2019 to Dec.2022 were selected as the study subjects,and they were divided into the control group without EB virus infection(70 cases),the previously infected group with pre-vious EB virus infection(30 cases),and the acutely infected group currently infected with EB virus infection(36 cases)according to whether they had EB virus infection and the status of their infection.The clinical data of the three groups were collected,and the coronary artery disease,as well as the expression of serum TIMP-1,NF-κB,and IκBα protein,and the index of inflammation were compared among the three groups.RESULTS The propor-tion of coronary artery injury(CAL)in the acutely infected group,the previously infected group,and the control group showed a decreasing trend(P＜0.05).The proportion of children with left circumflex artery(LCX)lesions in the acutely infected group was higher than that in the previously infected group and control group(P＜0.05).The expression levels of serum TIMP-1 and IκBα protein showed a trend of increase in the acutely infected group,the previously infected group and the control group(P＜0.05),while the expression level of serum NF-κB protein and serum C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),IL-6 and IL-8 showed a trend of decrease(P＜0.05).CONCLUSION Epstein-barr virus infection aggravated coronary artery dis-ease and inflammatory response in children with Kawasaki disease,which had an impact on the expression level of serum TIMP-1,NF-κB,IκBα protein and the level of infection indicators.
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