Pathogenic bacteria of secondary lung infection in children with bronchial asthma and their influencing factors
OBJECTIVE To investigate the pathogenic bacteria of secondary lung infection in children with bronchial asthma and their influencing factors.METHODS Totally 987 cases of children with bronchial asthma admitted to the Children's Hospital Affiliated to Zhengzhou University from Jan.2020 to Dec.2022 were selected as the re-search subjects,and they were divided into the infected group(70 cases)and the non-infected group(917 cases)according to whether lung infection occurred.The distribution of pathogenic bacteria in sputum samples of children with bronchial asthma secondary to lung infection was analyzed.The clinical data of the two groups were com-pared,and the influencing factors of lung infection secondary to bronchial asthma were summarized.RESULTS The incidence of lung infection secondary to bronchial asthma was 7.09％(70/987).A total of 84 strains of patho-genic bacteria were cultured and isolated,of which 56 strains of gram-negative bacteria accounted for 66.67％,24 strains of gram-positive bacteria accounted for 28.57％,and 4 strains of fungi accounted for 4.76％.Multivariate logistic regression analysis showed that length of hospital stay,irrational use of antibiotics,invasive operations,use of anti-asthmatic drugs,the number of asthma exacerbations were the influencing factors of secondary lung in-fections in bronchial asthma(OR=2.349,1.891,2.358,2.004,1.990,all P＜0.05).CONCLUSION The inci-dence of secondary lung infection of bronchial asthma was relatively high,and gram-negative bacteria were pre-dominant.The secondary lung infection of bronchial asthma was closely related to the length of hospital stay,the use of antibiotics,invasive procedures,the use of anti-asthmatic drugs,and the number of asthmas exacerbation.Therefore,targeted treatment and preventive measures can be taken to reduce the risk of lung infection secondary to bronchial asthma.
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