Distribution and drug resistance of clinical carbapenem-resistant Pseudomonas aeruginosa isolates from a three-A hospital in 2018-2022
OBJECTIVE To investigate the distribution and drug resistance of clinical carbapenem-resistant Pseudo-monas aeruginosa isolates from a three-A hospital in 2018-2022.METHODS Totally 2 358 strains of P.aerugino-sa were isolated from specimens that were submitted from clinical departments of the First Hospital of Jiaxing from Jan 1,2018 to Dec 31,2022.The strains were cultured and identified,the drug susceptibility testing was performed,and the distribution and drug resistance of the CRPA strains were statistically analyzed.RESULTS A total of 2 358 strains of P.aeruginosa were isolated from 2018 to 2022,407 of which were CRPA,and the total i-solation rate of CRKP strains was 17.26％;the isolation rate of CRPA strains generally showed a downward trend during the 5 years(P＜0.05).The elderly male patients with no less than 60 years of age were dominant among the patients with CRPA infection,and the isolation rate was relatively high in summer.Among the strains isolated from specimen sources,75.92％were isolated from sputum specimens,and 5.65％were isolated from urine speci-mens.Of the strains isolated from the clinical departments,24.32％were isolated from critical care medicine de-partment,15.48％were isolated from rehabilitation department,and 15.23％were isolated from respiratory medi-cine department.The drug resistance rates of the CRPA strains to imipenem and meropenem were 96.32％and 79.04％,respectively;the drug resistance rates to most of the cephalosporins,β-lactams and quinolones were more than 45％;the drug resistance rates to amikacin and gentamycin were less than 12％;the drug resistance rate to piperacillin-tazobactam showed an upward trend(P＜0.05);the drug resistance rate to amikacin,genta-mycin and ciprofloxacin showed a downward trend(P＜0.05).CONCLUSION It is necessary for the hospital to strengthen the monitoring of vulnerable population and drug resistance of CRPA strains from key department,in-tensify the submission of etiological specimens and clinical management of antibiotics,and take effective preven-tion and control measures so as to prevent the prevalence and transmission of the CRPA strains.
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