Clinical distribution and change of drug resistance of 119 Morganella morganii isolates
OBJECTIVE To investigate the clinical distribution and change of drug resistance of 119 isolates of Mor-ganella morganii.METHODS The clinical distribution,specimen sources,infection state,infection sites,results of drug susceptibility testing and changes of drug resistance of the 119 isolates of M.morganii were collected from the First People's Hospital of Changzhou by means of laboratory information management system and Xinglin Hospital Infection Real-time Monitoring System from Sep 2019 to Sep 2022.RESULTS The 119 isolates were mainly isolated from critical care medicine department,urinary surgery department and nephrology department.Urine,pus and sputum specimens were the major specimen sources.There were 22 strains of nosocomial infection and 55 strains of community-associated infection.Lower respiratory tract and bacteriemia were the major nosoco-mial infection sites;the urinary tract and skin soft tissue were the major community-associated infection sites;there was significant difference in the distribution between the types of infection sites(P＜0.05).Among the 119 isolates of M.morganii,carbapenem-resistant Enterobacter(CRE)accounted for 19.33％,and multidrug-resist-ant organisms(MDROs)accounted for 31.93％.There was no significant difference in the drug resistance of M.morganii isolates to penicillins,quinolones and cephalosporins among the three years,but there was significant difference in the drug resistance to imipenem of the carbapenems among the three years,and the drug resistance was increased with the years(P＜0.05).CONCLUSION The M.morganii may result in a variety of infections,the proportion of community-associated infection is higher than that of the nosocomial infection.The lower respiratory tract is the major nosocomial infection site.Amikacin can be used as the frontline drug for the clinical treatment of M.morganii infection.The isolation rate of carbapenem-resistant Morganella isolates is increased year by year.It is necessary for the hospital to reasonably use antibiotics based on the result of drug susceptibility testing and strengthen the surveillance of drug resistance.
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