2022年某院侵袭性念珠菌医院感染临床及流行病学特征
Cliniacl and epidemiological characteristics of nosocomial infection caused by invasire Candida from a hospital in 2022
臧凤 1刘娟 1李松琴 1张卫红 1李占结 1杨乐 2宋舸2
作者信息
- 1. 江苏省人民医院(南京医科大学第一附属医院,江苏省妇幼保健院)感染管理处,江苏南京 210029
- 2. 南京医科大学附属常州第二人民医院感染管理科,江苏常州 213000
- 折叠
摘要
目的 研究念珠菌分离及医院感染的流行病学特征,为控制侵袭性念珠菌医院感染提供依据.方法 回顾性收集江苏省人民医院2022年1月1日-2022年12月31日检出的7 667株假丝酵母及临床资料,分析假丝酵母分离来源及医院感染分布情况.结果 白假丝酵母整体分离率最高(58.49％),其次为近平滑假丝酵母(22.58％)、热带假丝酵母(15.52％)、光滑假丝酵母(2.13％)、克柔假丝酵母(1.02％),标本类型中来自于痰标本的菌株数量4 550株,占59.35％,其次为泌尿道(1 183株,15.43％)及粪便(682株,8.90％).分离科室最多是内科(2 879株,37.55％),其次为外科(2 366株,30.86％)、重症监护病房(ICU)(2 232株,29.11％)及急诊(190株,2.48％).共有688例患者发生侵袭性念珠菌医院感染,占全年医院感染的23.93％,年龄＞60岁的侵袭性念珠菌医院感染患者占66.72％(459/688),基础疾病以高血压和心血管疾病为主,感染科室主要在ICU(41.13％,283/688),住院时间主要集中在15～30 d(49.42％,340/688),抗菌药物使用时间≥3周的比例占65.12％(448/688).结论 侵袭性念珠菌医院感染的患者逐渐增多,侵袭性念珠菌医院感染与年龄、基础疾病、科室、住院时间、抗菌药物使用时间等因素有关,亟需加强医院防控.
Abstract
OBJECTIVE To investigate the epidemiological characteristics of nosocomial infection caused by Candi-da so as to provide basis for control of the Candida nosocomial infection.METHODS Totally 7 667 strains of Can-dida were isolated from Jiangsu Province People's Hospital from Jan 1,2022 to Dec 31,2022,the clinical data were also collected.The distribution of the Candida isolates and distribution of the nosocomial infection cases were observed.RESULTS The overall isolation rate of Candida albicans was the highest(58.49％),followed by Candida par a p silosis(22.58％),Candida tropicalis(15.52％),Candida glabrata(2.13％)and Candida krusei(1.02％).Among the strains isolated from the specimens,4 550(59.35％)were isolated from sputum specimens,1 183(15.43％)were isolated from urine specimens,and 682(8.90％)were isolated from stool specimens.Total-ly 2 879(37.55％)strains were isolated from internal medicine department,2 366(30.86％)strains were isolated from surgery departments,2 232(29.11％)strains were isolated from intensive care unit(ICU),and 190(2.48％)strains were isolated from emergency department.A total of 688 patients had invasive Candida nosoco-mial infection,accounting for 23.93％among the patients with nosocomial infection in the whole year;the patients with invasive Candida infection who were more than 60 years old accounted for 66.72％(459/688).Hypertension and cardiovascular disease were the major underlying diseases.ICU was dominant among the departments with in-fections,accounting for 41.13％(283/688),the major length of hospital stay was 15-30 days(49.42％,340/688).The proportion of patients who were treated with antibiotics for no less than 3 weeks accounted for 65.12％(448/688).CONCLUSION The patients who have invasive Candida nosocomial infection are increasingly high.The invasive Candida nosocomial infection is associated with the age,underlying disease,department,length of hospital stay and antibiotic treatment duration.It is necessary for the hospital to strengthen the preven-tion and control.
关键词
医院感染/侵袭性/真菌/假丝酵母/流行病学分布/感染防控/侵袭性念珠菌病Key words
Nosocomial infection/Invasive/Fungus/Candida/Epidemiological distribution/Infection prevention and control/Invasive candidiasis引用本文复制引用
基金项目
国家重点研发计划(2020YFC0848100)
江苏省医院协会医院管理创新研究课题(JSYGY-3-2020-692)
江苏省医院协会医院管理创新研究课题(JSYGY-3-2019-48)
江苏省人民医院第三期优秀中青年人才培养基金(YNRCQN0314)
南京医科大学第一附属医院青年基金培育基金(PY2022017)
出版年
2024
NETL
NSTL
万方数据