Impact of pulmonary function on risk of respiratory tract infection in patients with bronchial asthma
OBJECTIVE To explore the impact of pulmonary function on risk of respiratory tract infection in the pa-tients with bronchial asthma based on Kaplan-Meier method and Cox proportional hazard regression model.METHODS A total of 398 patients with bronchial asthma who were treated in respiratory department of Ningbo Traditional Chinese Medicine Hospital from Jun 2019 to Jun 2023 were recruited as the research subjects and were divided into the normal pulmonary function group with 110 cases and the reduced pulmonary function group with 288 cases according to the level of pulmonary function.The incidence of respiratory tract infection was compared between the two groups of patients,the survival curves were drawn by Kaplan-Meier method,the cumulative morbidity rate was calculated,and the impact of pulmonary function level on newly onset of respiratory tract infec-tion incident was observe by Cox proportional hazard regression model.RESULTS The average follow-up of the two groups of patients was(20.43士 5.80)months.Totally 157 cases had respiratory tract infection,the total inci-dence density of respiratory tract infection among the population was 2.9/10 000 months;the incidence density of respiratory tract infection was 3.2/10 000 months in the reduced pulmonary function group,1.2/10 000 months in the normal pulmonary function group.The cumulative morbidity rate of the reduced pulmonary function group was 20.13％(58/288),significantly higher than 15.45％(17/110)of the normal pulmonary function group(P＜0.05).The Cox proportional hazard regression model indicated that the reduced pulmonary function group was as 1.56 times the risk for respiratory tract infection as the normal pulmonary function group[95％CI(0.541-4.499)];the reduced pulmonary function group was as 1.07 times the risk of respiratory tract infection as the normal pulmonary function group after the indexes(age,smoking history,administration of hormone,hemoglobin level)with sig-nificant differences between the two groups at the baseline were adjusted[95％CI(0.829-1.385)].CONCLUSION The decline of pulmonary function is a leading risk factor for the incidence of respiratory tract infection.It is sug-gested that the improvement of pulmonary function should be taken as an important measure for prevention of re-spiratory tract infection in the bronchial asthma patients.
NETL
NSTL
万方数据
