首页|肝硬化并发自发性细菌性腹膜炎的危险因素及其与TRAF6基因多态性的关联

肝硬化并发自发性细菌性腹膜炎的危险因素及其与TRAF6基因多态性的关联

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目的 分析肝硬化并发自发性细菌性腹膜炎(SBP)的危险因素及其与肿瘤坏死因子受体相关因子6(TRAF6)基因多态性的关联。方法 纳入2018年6月-2022年1月桐乡市第一人民医院收治的肝硬化患者153例进行研究，根据其并发SBP情况，分为SBP组52例、非SBP组101例。分析两组TRAF6基因多态性，通过单因素分析及多因素Logistic回归分析法分析肝硬化并发SBP的危险因素。结果 肝硬化患者153例，并发SBP 52例，占比为33。99％，SBP组TRAF6基因rs5030445位点AA型占比高于非SBP组(P＜0。05)。与非SBP组比较，SBP组年龄＞60岁、Child-Pugh分级C级、合并上消化道出血、合并肝性脑病、合并肝肾综合征，血清总胆红素(TBil)水平升高，腹水白蛋白(Alb)水平降低(P＜0。05)。多因素Logistic分析结果显示，年龄＞60岁、Child-Pugh分级C级、合并肝性脑病、TRAF6基因rs5030445位点AA型为肝硬化并发SBP的危险因素(P＜0。05);腹水Alb水平升高为肝硬化并发SBP的保护因素(P＜0。05)。结论 肝硬化并发SBP的发生率为33。99％，其发生与TRAF6基因多态性密切相关，肝硬化并发SBP的危险因素较多，可为预防措施的制定提供依据。
Risk factors for spontaneous bacterial peritonitis in liver cirrhosis patients and association with TRAF gene polymorphisms
OBJECTIVE To explore the risk factors for spontaneous bacterial peritonitis(SBP)in the liver cirrhosis patients and analyze the association with gene polymorphisms of tumor necrosis factor receptor-associated factor 6(TRAF6).METHODS Totally 153 patients with liver cirrhosis who were treated in Tongxiang First People's Hos-pital from Jun 2018 to Jan 2022 were enrolled in the study and were divided into the SBP group with 52 cases and the non-SBP group with 101 cases according to the status of complication with SBP.The TRAF6 gene polymor-phisms were analyzed.Univariate analysis and multivariate logistic regression analysis were performed for the risk factors for the SBP in the liver cirrhosis patients.RESULTS Of the 153 liver cirrhosis patients,52 were complicat-ed with SBP,accounting for 33.99％.The frequency of AA genotype at rs5030445 locus of TRAF6 gene was sig-nificantly higher in the SBP group than in the non-SBP group(P＜0.05).The proportions of the patients with more than 60 years of age,grade C of Child-Pugh,complication of upper gastrointestinal hemorrhage,complica-tion of hepatic encephalopathy,complication of hepatorenal syndrome and the serum total bilirubin(TBil)level were significantly higher in the SBP group than in the non-SBP group;while the ascites albumin(Alb)level of the SBP group was significantly lower than that of the non-SBP group(P＜0.05).The result of multivariate logistic a-nalysis showed that the more than 60 years of age,grade C of Child-Pugh,complication with hepatic encephalopa-thy and genotype AA at rs5030445 locus of TRAF6 were the risk factos for the SBP in the liver cirrhosis patients(P＜0.05);the rise of ascites Alb level was the protective factor for SBP in the liver cirrhosis patients(P＜0.05).CONCLUSION The incidence rate of SBP is 33.99％among the liver cirrhosis patients,the incidence is closely as-sociated with the TRAF6 gene polymorphisms.There are a variety of risk factors for the SBP in the liver cirrhosis patients.It can provide bases for formulating prevention measures.

Liver cirrhosisSpontaneous bacterial peritonitisTumor necrosis factor receptor-associated factor 6Gene polymorphismRisk factorAssociation

杨三霞、戚昉、吴丽娟、龚文兰、杨佳慧、熊志斌、沈越利

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桐乡市第一人民医院感染科,浙江桐乡 314500

肝硬化 自发性细菌性腹膜炎 肿瘤坏死因子受体相关因子6 基因多态性 危险因素 关联

浙江省医药卫生科技计划基金资助项目桐乡市科技局引导基金资助项目

2022ky277201803099

2024

10.11816/cn.ni.2024-231060

中华医院感染学杂志
中华预防医学会 中国人民解放军总医院

中华医院感染学杂志

CSTPCD北大核心
影响因子：1.885
ISSN：1005-4529
年,卷(期)：2024.34(5)
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