Clinical characteristics laboratory diagnosis of brucellosis in non-pastoral areas from 2016 to 2022
OBJECTIVE To explore the clinical characteristics and diagnostic methods of brucellosis in non-pastoral areas and observe the characteristics of culture of Brucella.METHODS A total of 36 patients with brucellosis who were treated in the Third People's Hospital of Changzhou from 2016 to 2022 were recruited as the research sub-jects.The characteristics of bacterial culture,clinical characteristics,prevention and treatment were respectively analyzed.The biomarkers for the brucellosis were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS The male and middle-aged patients were dominant among the 36 patients with brucellosis.The patients had a clear epidemiological contact history of contact with cattle and sheep.Among the 36 patients,fever complicated with night sweating was the major clinical symptom,followed by joint sore,with the knee-joint sore dominant.Testicular pain was rare.Lumbar vertebra bone destruction was the most common complication,fol-lowed by Brucella encephalitis.The result of clinical laboratory test showed that the levels of C-reactive protein(CRP)and serum amyloid A(SAA)were elevated.Both white blood cell counts and procalcitonin(PCT)were normal.The blood culture of 28 patients was reported for positive growth in aerobic bottle,and all were identified as Brucella ovis.18 patients were tested positive for Brucella antibody,1 of whom was identified as Brucella ovis by the next generation sequencing.Doxycycline combined with rifampicin was the most common drug therapy.To-tally 35 patients were cured and improved,and 1 patient abandoned the drug therapy.ROC curve analysis indica-ted that when the critical value of CRP was 4.81 mg/L,the sensitivity and specificity were 93.30％and 89.50％,respectively.CONCLUSION The brucellosis shows diversified clinical manifestations,there is no specificity in the clinical laboratory test.It is necessary to strengthen the clinical laboratory test of Brucella and combine with the epidemiological history for the patients with unknown origin.
BrucellosisNon-pastoral areaClinical manifestationBloodstream infectionBiomarker for infec-tionLaboratory diagnosis
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