Value of serum HBP and pro-ADM in monitoring of central venous catheter-related bloodstream infection of patients undergoing malignant tumor chemoradiotherapy
OBJECTIVE To explore the values of serum heparin-binding protein(HBP)and pro-adrenomedullin(pro-ADM)in monitoring of central venous catheter-related bloodstream infection in the patients undergoing che-moradiotherapy.METHODS From Jan 2019 to Jan 2021,totally 52 patients who underwent malignant tumor che-moradiotherapy in Hai'an Hospital Affiliated to Nantong University and had central venous catheter-related blood-stream infection were assigned as the infection group,and 30 patients who did not have bloodstream infection were chosen as the no infection group.The patients of the infection group were divided into the survival group with 37 cases and the death group with 15 cases according to the 28-day survival status.The expression levels of serum HBP and pro-ADM were compared among the groups,and the value of the serological indexes in assessment of prognosis were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS The levels of ser-um HBP and pro-ADM of the infection group were higher than those of the no infection group(P＜0.05).The ser-um HBP level of the patients with gram-negative bacteria infection were higher than that of the patients with gram-positive bacteria infection(P＜0.05).The expression levels of serum HBP and pro-ADM of the death group were higher than those of the survival group on the 1st,3rd and 5th day after the infection occurred(P＜0.05).The area under ROC curve of the joint detection of serum HBP and pro-ADM was 0.840 on the 3rd day after the infection occurred,0.852 on the 5th day after the infection occurred,higher than 0.744 on the 1st day(P＜0.05).CONCLUSION The patients who undergo the malignant tumor chemoradiotherapy and have central venous cathe-ter-related bloodstream infection show the rise of serum HBP and pro-ADM,and the dynamic monitoring has sig-nificant value in assessment of the prognosis.
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