Risk factor for postoperative surgical site infection in neurosurgery department patients undergoing deep brain stimulation
OBJECTIVE To explore the risk factors for postoperative surgical site infection(SSI)in the patients un-dergoing deep brain stimulation(DBS).METHODS A total of 431 patients who underwent DBS implantation(in-cluding DBS reimplantation)and implantable pulse generator(IPG)replacement surgery in neurosurgery depart-ment of the Second Affiliated Hospital of Air Force Military Medical University from Jan 1,2018 to Dec 31,2022 were recruited as the research subjects,25 patients had SSI,and 406 did not have infection.The characteristics of postoperative infection in the DBS patients were analyzed,and the risk factors for the postoperative SSI in the DBS patients were screened out.RESULTS Totally 504 case-times of patients received surgical procedures among the 431 patients.A total of 608 electrodes were placed in 298 patients.The incidence of SSI was 4.96％after the DBS implantation and IPG replacement surgery,the incidence of infection was 5.03％among the patients who under-went DBS for the first time,the incidence of infection was 4.00％among the patients undergoing IPG replacement surgery,the incidence of infection due to electrodes was 0.33％.Totally 2(0.46％)patients had SSI within 90 days after the surgery,7(1.62％)patients had infection within 6 months after the surgery.A follow-up showed that 12(2.78％)patients had infection after the surgery for 6 months to 1 year,and 4(0.93％)had infection after the surgery for 1 year.Totally 9 strains of pathogens were isolated,7 of which were gram-positive bacteria,and 2 were gram-negative bacteria.Staphylococcus aureus(4 strains)was dominant among the pathogens.Logistic re-gression analysis showed that body mass index(BMI)and blood glucose were the risk factors for the postoperative infection in the DBS patients(P＜0.05).CONCLUSION BMI and blood glucose are the risk factors for the postop-erative SSI in the DBS patients.The incidence of infection is higher among the patients who undergo DBS implan-tation for the first time than among the patients who undergo IPG replacement surgery.Surgical removal of hard-ware is the first choice for the patients with deep infection to control the infection.
Neurosurgery departmentDeep brain stimulatorSurgical site infectionRisk factorRemoval of hardware
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