Effect of anti-HPV bioprotein dressings combined with promestriene cream on treatment of postmenopausal women with cervical HPV infection
OBJECTIVE To explore the effectiveness and safety of anti-human papillomavirus(HPV)bioprotein dressings combined with promestriene cream in treatment of postmenopausal women with cervical HPV infection.METHODS Totally 228 postmenopausal women with high-risk HPV(HR-HPV)infection who were treated in the PLA Rocket Force Characteristic Medical Center from Mar 2018 to Aug 2022 were retrospectively analyzed.124 patients who were treated with anti-HPV bioprotein dressings combined with promestriene cream were assigned as the study group,and 104 patientsr who were treated with Baofukangshuan were assigned as the control group.The baseline data were collected from the patients,both groups were treated for 3 months,Thinprep Cytologic Test(TCT),HPV and vaginal microecosystem indexes were detected before the treatment and after the treatment for 3 months.The result of HPV test,vaginal microecosystem indexes and incidence of adverse reactions were ob-served and compared between the study group and the control group before and after the treatment.RESULTS There were no significant differences in the age,menopausal time and number of subtypes of HR-HPV infection between the two groups.The abnormal rate of vaginal microecosystem,pH value and Nugent score of the study group were reduced after the treatment(P＜0.05).The cure rate of the study group was 34.7％,higher than that of the control group;the total effective rate of the study group was 65.3％,higher than that of the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups.CONCLUSION The anti-HPV bioprotein dressings combined with promestriene cream may improve the vaginal microecosystem and facilitate the negative turn of HR-HPV of the postmenopausal women,it is highly effective and safe.
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