Risk factors for Epstein-Barr virus infection-associated infectious mononucleosis and pneumonia in children
OBJECTIVE To explore the risk factors for Epstein-Barr virus(EBV)infection-associated infectious mononucleosis(IM)and pneumonia in the children.METHODS The clinical data were collected from 155 children who were diagnosed with EBV infection-associated IM and were treated in department of integrated traditional Chinese medicine and western medicine of Wuhan Children's Hospital,Tongji Medical College,Huazhong Univer-sity of Science and Technology from Jul 2020 to Jun 2022.The children were divided into the pneumonia group with 46 cases and the no pneumonia group with 109 cases according to the status of complication with pneumonia.The clinical data were collected from the two groups of children.Univariate analysis and multivariate logistic re-gression analysis were performed for the risk factors for the EBV infection-associated IM and pneumonia.The pre-dictive efficiencies of the risk factors were evaluated by means of receiver operating characteristic(R()C)curve.RESULTS Among the 155 children,46 were complicated with pneumonia,accounting for 29.7％.The result of un-ivariate analysis showed that there were significant differences in the age,duration of fever and blood antibody titer of M.pneumoniae(P＜0.05).The result of multivariate logistic regression analysis indicated that the age and blood antibody titer of M.pneumoniae were the risk factors for EBV infection-associated IM and pneumonia in the chil-dren(P＜0.05).The 51 months of age was the optimal critical value for the EBV infection-associated IM and pneumonia.CONCLUSION There is a high proportion of the children with EBV infection-associated IM and pneu-monia.The less than 51 months of age and blood antibody titer of M.pneumoniae no less than 1∶160 are the risk factors for the EBV infection-associated IM and pneumonia.It is necessary to perform the complete chest imaging examination during the clinical diagnosis and treatment.
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