Influence of congenital human cytomegalovirus infection on coagulation function,iron metabolism,growth and development of neonates
OBJECTIVE To observe the influence of congenital human cytomegalovirus(HCMV)infection in coagu-lation function,iron metabolism,growth and development of neonates.METHODS A total of 127 neonates with congenital HCMV infection who were treated in Shaoxing Central Hospital from Jul 2021 to Dec 2022 were as-signed as the study group,meanwhile,125 healthy neonates were chosen as the control group.The coagulation in-dexes[fibrinogen(FIB).D-dimer(D-D),platelet count(PLT),activated partial thromboplastin time(APTT),prothrombin time(PT)],iron metabolism indexes[serum iron(SI),serum ferritin(SF),serum transferrin(TRF),hemoglobin(Hb)]and growth and development were observed and compared between the two groups.RESULTS The restriction of intrauterine growth,pathological jaundice and thrombocytopenia were the common clinical characteristics among the neonates in the study group,the incidence rates were 28.35％(36/127),23.62％(30/127)and 21.26％(27/127),respectively.The levels of FIB and D-D of the study group were higher than those of the control group,while the levels of PLT,APTT,PT、SI,SF,TRF and Hb of the study group were lower than those of the control group(P＜0.05).There were no significant differences in the body weight,head circumference,height and high hip between the two groups of neonates at the birth and after the birth for 6 months.The incidence of monaural and binaural hearing impairment of the study group was higher than that of the control group after the birth for 6 months(P＜0.05).The DQ values of neonatal adaptability,gross motor ability,fine motor and speech expression of the study group were lower than those of the control group(P＜0.05).CONCLUSION The congenital HCMV infection may affect the coagulation function and iron metabolism of the ne-onates and increase the risk of hearing and nerve injury.
Human cytomegalovirusCongenital infectionCoagulation functionIron metabolismGrowth and development
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