Correlation of serum SIL-2R,CHE,Ang-2 levels with the prognosis in patients with acute myocardial infarction and pulmonary infection
OBJECTIVE To explore the correlation of serum soluble interleukin-2 receptor(SIL2R),cholinesterase(CHE)and angiotensin-2(Ang-2)with the prognosis in patients with acute myocardial infarction(AMI)and pul-monary infection.METHODS A total of 88 patients with AMI admitted to cardiology department of Xinxiang Cen-tral Hospital between Jan 2022 and Jan 2023 were enrolled as the research subjects.According to whether pulmo-nary infection occurred during hospitalization,they were divided into the infection group(n=36)and noninfec-tion group(n=52).According to major adverse cardiovascular events(MACE)within 6 months after discharge,they were divided into the good prognosis group(n=67)and poor prognosis group(n=21).The level of serum SIL-2R was detected by double-antibody sandwich method,level of serum CHE was detected by enzyme-linked immunosorbent assay,and level of serum Ang-2 was detected by radioimmunoassay.The peak oxygen uptake and forced expiratory volume in the first second(FEV1)were detected and recorded.The cardiac function was evalua-ted by Killip grading.The relationship between serum SIL-2R,CHE and Ang-2 levels and Killip grading was ana-lyzed by Spearman correlation analysis,and the correlation of serum SIL-2R,CHE and Ang-2 levels with FEV1 and peak oxygen uptake was analyzed by Pearson correlation analysis.RESULTS The serum levels of SIL-2R and Ang-2 in the infection group were significantly higher than those in the non-infection group,while CHE level was significantly lower than that in the non-infection group(P＜0.05).The serum levels of SIL-2R and Ang-2 in the poor prognosis group were significantly higher than those in the good prognosis group,while CHE level was sig-nificantly lower than those in the good prognosis group(P＜0.05).There were significant differences in Killip grading,FEV1 and peak oxygen uptake between the poor prognosis group and good prognosis group.FEV1 and peak oxygen uptake in the poor prognosis group were significantly lower than those in the good prognosis group(P＜0.05).The levels of serum SIL-2R and Ang-2 were positively correlated with Killip grading,while negatively correlated with FEV1 and peak oxygen uptake.The level of serum CHE was negatively correlated with Killip grad-ing,while positively correlated with FEV1 and peak oxygen uptake(P＜0.05).CONCLUSION The levels of ser-um SIL-2R,CHE and Ang-2 are not only correlated with pulmonary infection in AMI patients,but also correlated with prognosis.
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