Risk factors for neurosurgical surgical site infection and diagnostic value of SAA and HBP
OBJECTIVE To investigate the incidence of surgical site infection in neurosurgery and to analyze the di-agnostic value of serum amyloid A(SAA)and heparin-binding protein(HBP)for infections.METHODS A retro-spective survey was conducted on 2 930 neurosurgical patients in Lishui Central Hospital from Jan 2019 to Dec 2022,and the surgical site infection was recorded and the general clinical data of different infection types and dis-tribution of pathogenic bacteria in patients with infection were analyzed.Multivariate logistic regression was used to analyze the independent influencing factors of surgical site infections,and the ROC curve was drawn to assess the predictive value of SAA and HBP levels on the first day after surgery for surgical site infections.RESULTS A-mong 2 930 patients,there were 47 cases of postoperative surgical site infection with the incidence rate of 1.60％,including 9 cases of superficial incision infection(19.15％)and 38 cases of organ lacunar infection(80.85％).Bacteria were detected in 33 cases of 47 patients with incision infection,among which Staphylococcus aureus was the most common pathogen,accounting for 36.54％.Multivariate logistic regression analysis showed that the cleanliness level of the operating room,the use of implants,and the serum levels of SAA and HBP after surgery were independent factors related to surgical site infections(P＜0.05).The ROC curve showed the combined pre-dictive value of SAA and HBP after surgery for surgical site infections,with the sensitivity of 83.91％,specificity of 67.92％,and an area under the curve of 0.860.CONCLUSION The incidence rate of surgical site infection after neurosurgical procedure is relatively high,and S.aureus is the main pathogen.The cleanliness level of the operat-ing room,the use of implants,and the serum levels of SAA and HBP are independent factors associated with in-fections.Notably,the predictive value of SAA and HBP combined detection plays a significant clinical role in pre-dicting surgical site infections.
Neurosurgical procedureSurgical site infectionPathogenic bacteriaRisk factorSerum amyloid AHeparin-binding protein
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