Correlation of serum miR-204,miR-101,miR-181b expression levels with TNM stages and Helicobacter pylori infection in patients with gastric cancer
OBJECTIVE To investigate the correlation of the expression of serum miR-204,miR-101,miR-181b with different TNM stages and Helicobacter pylori(Hp)infection in patients with gastric cancer.METHODS A total of 102 patients with gastric cancer(as the case group)and 110 patients with gastritis(as the control group)admitted to Wuwei Hospital of Traditional Chinese Medicine from Oct 2018 to Dec 2022 were retrospectively in-cluded in the study and the clinical data were analyzed.Serum levels of miR-204,miR-101 and miR-181b were de-tected and compared between the two groups,among patients with gastric cancer with different Hp infection and different TNM stages.Spearman method was used to analyze the correlation between serum miR-204,miR-101,miR-181b levels and different TNM stages and Hp infection in patients with gastric cancer.RESULTS The serum levels of miR-204 and miR-101 in the case group were decreased compared with those in the control group(P＜0.05),while the serum level of miR-181b was increased(P＜0.05).The serum levels of miR-204 and miR-101 in gastric cancer patients at Ⅲ-Ⅳ stage,with lymph node metastasis and HP-positive infection were lower than those at Ⅰ-Ⅱ stage,with HP-negative and without lymph node metastasis(P＜0.05),while the level of miR-181b were higher(P＜0.05).Spearman correlation analysis showed that serum miR-204 and miR-101 levels were nega-tively correlated with Hp infection and high TNM stages in gastric cancer patients(P＜0.05),and serum miR-181b levels were positively correlated with Hp infection and high TNM stages(P＜0.05).CONCLUSION Serum miR-204 and miR-101 expression levels are low in gastric cancer,while miR-181b is highly expressed in gastric cancer.The levels of the three indexes are closely related to the progression of gastric cancer and Hp infection.In addition,serum miR-204 and miR-101 levels are negatively correlated with Hp infection and higher TNM stages,while serum miR-181b level was positively correlated with Hp infection and higer TNM stages.
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