Diagnostic value of the combination of serum carcinoembryonic antigen and C-reactive protein in the early postoperative infection in patients after radical rectal cancer ostomy
OBJECTIVE To investigate the value of serum carcinoembryonic antigen(CEA)combined with C-reac-tive protein(CRP)in the early diagnosis of postoperative infection in patients with radical rectal cancer.METHODS A total of 82 rectal cancer patients undergoing radical surgery in the Second Affiliated Hospital of Nan-tong University from Jan 2021 to Jan 2023 were enrolled as study subjects.They were divided into the infected group(n=28)and non-infected group(n=54)according to whether postoperative infection occurred.Clinical data of all patients were collected three days before surgery and 4 ml venous blood was taken on the morning of admis-sion,which was used to detect CEA and CRP levels.The expression levels of CEA and CRP were compared a-mong patients with different clinical and pathological characteristics in the infected group,and the efficacy of CEA and CRP in the early diagnosis of radical rectal cancer was analyzed by receiver operating characteristic(ROC)curve for rectal cancer analyzing.RESULTS The levels of CEA and CRP in the infected group were higher than those in the non-infected group,and the differences were statistically significant(P＜0.05).There were significant differences in CEA levels among different tumor sizes,pathological types and ALB levels(P＜0.05).There were significant differences in CRP levels among patients with different age,tumor size,differentiation degree,TNM stage,pathological type and ALB level(P＜0.05).ROC curve analysis showed that CEA,CRP and AUC were 0.685,0.817 and 0.825,respective-ly(P＜0.05).The sensitivity of combined diagnosis of CEA and CRP was higher than that of the individual detection,and the difference was statistically significant(P＜0.05).CONCLUSION The combination of CEA and CRP has good clinical value for postoperative infection after radical rectal cancer stoma,which can improve the sensitivity and ac-curacy of clinical diagnosis of rectal cancer.Monitoring the changes of CEA and CRP levels can provide an impor-tant basis for clinical diagnosis of rectal cancer.
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