Correlation between polymorphisms of rs9282861 of sulfotransferase A1 gene and different pathogens infected in patients with pelvic inflammatory disease
OBJECTIVE To analyze the rs9282861 polymorphism of sulfotransferase A1(SULT1A1)gene and the distribution of pathogens in patients with pelvic inflammatory disease.METHODS A total of 116 patients with pel-vic inflammatory disease admitted to Xinyu People's Hospital from Jan 2019 to Aug 2022 were retrospectively in-cluded in the study group,of which 37 were mild,49 were moderate and 30 were severe,respectively.One hun-dred and twenty-five healthy women during this period were recruited in the control group.The pathogenic distri-bution of ureaplasma urealyticum,mycoplasma hominis,gonococcal bacteria and pelvic secretions between the study group and control group,and among patients with different degrees of pelvic inflammatory dis-ease.Rs9282861 polymorphisms of SULT1A1 gene in the study group and control group were analyzed and the correlation with Ureaplasma urealyticum,Mycoplasma hominis,Gonorrhoeae infection and distribution of bacte-ria in pelvic secretions was analyzed.RESULTS The AA genotype frequency of rs9282861 site at SULT1A1 gene in the study group was higher than that in the control group(P＜0.05).The infection rate of Ureaplasma urea-lyticum,Mycoplasma hominis and Gonococcus,the density of vaginal flora Ⅰ+Ⅳ,the diversity of vaginal flora Ⅰ+Ⅳ,the proportion of microecological abnormalities and the total detection rate of pathogenic bacteria in the study group were higher than those in the control group(P＜0.05).The infection rates of Ureaplasma urealytic-um,Mycoplasma hominis and Gonococcus,the density of vaginal flora Ⅰ+Ⅳ,the diversity of vaginal flora Ⅰ+Ⅳ,the proportion of microecological abnormalities and the total detection rate of pathogenic bacteria in patients with mild pelvic inflammatory disease,moderate pelvic inflammatory disease and severe pelvic inflammatory dis-ease showed an increasing trend(P＜0.05).Spearman correlation analysis showed that Ureaplasma urealyticum,Mycoplasma hominis,Gonococcus infection and rs9282861 AA genotype frequency of SULT1A1 gene were posi-tively correlated with vaginal flora density Ⅰ+Ⅳ,vaginal flora diversity Ⅰ+Ⅳ and proportion of microecological abnormalities(P＜0.05).CONCLUSION SULT1A1 gene rs9282861 AA genotype has higher susceptibility to pel-vic inflammatory disease.Ureaplasma urealyticum,Mycoplasma hominis and Gonococcus infection were impor-tant factors for the occurrence and development of pelvic inflammatory disease,and were closely related to the dis-tribution of bacterial flora in pelvic secretions.
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