首页|血清FABP4和PPARγ与miR-31-5p对子痫前期并发Hp感染患者妊娠结局的预测价值

血清FABP4和PPARγ与miR-31-5p对子痫前期并发Hp感染患者妊娠结局的预测价值

Predictive value of serum FABP4,PPARy and miR-31-5p on pregnancy outcomes in pregnant women with preeclampsia complicated by Hp infection

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目的 研究血清脂肪酸结合蛋白4(FABP4)、过氧化物酶体增殖物激活受体γ(PPARγ)、微小核糖核酸-31-5p(miR-31-5p)在预测子痫前期(PE)并发幽门螺杆菌(Hp)感染患者妊娠结局中的应用价值,为患者不良妊娠结局发生的早期诊断提供参考和依据.方法 回顾性选取2020年1月-2022年6月舟山市妇女儿童医院收治的198例PE并发Hp感染患者,分为结局不良组(75例)和结局良好组(123例),分组依据为妊娠结局.统计PE并发Hp感染患者不良妊娠结局发生情况,比较两组基础资料、血清FABP4、PPARγ、miR-31-5p水平,分析上述血清学指标对PE并发Hp感染患者不良妊娠结局的预测价值.结果 198例PE并发Hp感染患者总不良妊娠结局发生例数75例,总不良妊娠结局发生率为37.88％;结局不良组分娩孕周更短,剖宫产率更高(P＜0.05);结局不良组血清FABP4、miR-31-5p水平更高,血清PPARγ水平更低(P＜0.05);血清FABP4、PPARγ、miR-31-5p联合预测PE并发Hp感染患者不良妊娠结局的曲线下面积(AUC)值、敏感度、特异度均高于三者单独检测(P＜0.05).结论 发生不良妊娠结局的PE合并Hp感染患者孕期较短且多为剖宫产分娩,血清FABP4、PPARγ、miR-31-5p水平对其不良妊娠结局发生的预测价值较高.
OBJECTIVE To investigate the application value of serum fatty acid-binding protein 4(FABP4),peroxi-some proliferator-activated receptor γ(PPARy)and micrornas 31-5p(miR-31-5p)in predicting pregnancy out-comes in patients with preeclampsia(PE)complicated with Helicobacter pylori(Hp)infection,providing refer-ence and basis for early diagnosis of adverse pregnancy outcomes.METHODS A total of 198 PE patients with Hp infection admitted to Zhoushan Women and Children's Hospital from Jan 2020 to Jun 2022 were retrospectively collected and divided into the adverse outcome group(75 cases)and good outcome group(123 cases)according to the pregnancy outcomes.The incidence of adverse pregnancy outcomes in PE patients with Hp infection was ana-lyzed,and the general data,serum FABP4,PPARγ and miR-31-5p levels between the two groups were com-pared.Above serological indexes were analyzed to evaluate the predictive value on adverse pregnancy outcomes in PE patients with Hp infection.RESULTS Among 198 PE patients with Hp infection,75 patients had adverse pregnancy outcomes,and the incidence of total adverse pregnancy outcomes was 37.88％.The gestational week of delivery was shorter and the cesarean section rate was higher in the adverse outcome group(P＜0.05).The levels of serum FABP4 and miR-31-5p in the adverse group were higher while the level of serum PPARγ was lower(P＜0.05).The area under the curve(AUC)value,sensitivity and specificity of serum FABP4,PPARy and miR-31-5p combined detection to predict adverse pregnancy outcomes in patients with PE complicated with Hp infection were higher than those of the individual detection(P＜0.05).CONCLUSION PE patients with Hp infection have shorter gestation and are delivered by cesarean section.Serum FABP4,PPARγ and miR-31-5p levels may have higher predictive value on adverse pregnancy outcomes.

PreeclampsiaHelicobacter pyloriFatty acid binding protein 4Peroxisome proliferator activated re-ceptor γMicrornas 31-5pPregnancy outcome

张霞、陈艳洁、戴方娣

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舟山市妇女儿童医院产科,浙江舟山 316000

舟山市妇女儿童医院新生儿科,浙江舟山 316000

子痫前期 幽门螺杆菌 脂肪酸结合蛋白4 过氧化物酶体增殖物激活受体γ 微小核糖核酸-31-5p 妊娠结局

浙江省医药卫生科技计划基金资助项目舟山科技计划基金资助项目

2020KY10002023C31017

2024

10.11816/cn.ni.2024-231256

中华医院感染学杂志
中华预防医学会 中国人民解放军总医院

中华医院感染学杂志

CSTPCD北大核心
影响因子：1.885
ISSN：1005-4529
年,卷(期)：2024.34(7)
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